Adipogen/Auranofin/AG-CR1-3611-M100/100 mg
商品编号：
AG-CR1-3611-M100
品牌：
Adipogen Inc
市场价：
¥1200.00
美元价：
720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetra- acetate; NSC 321521; SKF 39162 |
| Product Type | Chemical |
| Properties | |
| Formula | C20H34AuO9PS |
| MW | 678.5 |
| Merck Index | 14: 878 |
| CAS | 34031-32-8 |
| RTECS | MD6500000 |
| Purity Chemicals | ≥98% |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or 100% ethanol. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | AUJRCFUBUPVWSZ-XTZHGVARSA-M |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Anti-inflammatory and anti-arthritic agent. Represses the activation of the NLRP3/IL-1β pathway.
- Inhibitor of 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKβ subunit 5.
- Potent thioredoxin reductase (TrxR) inhibitor. Induces mitochondrial membrane permeability transition.
- Anti-cancer compound with anti-proliferative activity. Shown to induce apoptosis and necrosis.
- STAT3 and telomerase activity inhibitor.
- Proteasomal deubiquitinase inhibitor.
- Antibiotic, antiviral and antiparasitic compound.
- Immunosuppressive.
Product References
- Auranofin. New oral gold compound for treatment of rheumatoid arthritis: A.E. Finkelstein, et al.; Ann. Rheum. Dis. 35, 251 (1976)
- Inhibition of alveolar macrophage 5-lipoxygenase metabolism by auranofin: M. Peters-Golden & C. Shelly; Biochem. Pharmacol. 38, 1589 (1989)
- Gold compound auranofin inhibits IkappaB kinase (IKK) by modifying Cys-179 of IKKbeta subunit: K.I. Jeon, et al.; Exp. Mol. Med. 35, 61 (2003)
- Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells: C. Marzano, et al.; Free Radic. Biol. Med. 42, 872 (2007)
- Auranofin, an immunosuppressive drug, inhibits MHC class I and MHC class II pathways of antigen presentation in dendritic cells: S. Han, et al.; Arch. Pharm. Res. 31, 370 (2008)
- The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-κB activity: A. Nakaya, et al.; Leuk. Res. 35, 243 (2011)
- The biological activity of auranofin: implications for novel treatment of diseases: J.M. Madeira, et al.; Inflammopharmacology 20, 297 (2012) (Review)
- Antiproliferative effect of gold(I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells: N.H. Kim, et al.; BMB Rep. 46, 59 (2013)
- Drug repositioning: auranofin as a prospective antimicrobial agent for the treatment of severe staphylococcal infections: M.I. Cassetta, et al.; Biometals 27, 787 (2014)
- Suppression of the pro-inflammatory NLRP3/interleukin-1β pathway in macrophages by the thioredoxin reductase inhibitor auranofin: E. Isakov, et al.; Biochim. Biophys. Acta 1840, 3153 (2014)
- Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth: M. Liu, et al.; Oncotarget 5, 5453 (2014)
- Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion: B.R. You, et al.; Mol. Med. Rep. 11, 1428 (2015)
- Auranofin: repurposing an old drug for a golden new age: C. Roder & M.J. Thomson; Drugs R.D. 15, 13 (2015) (Review)
- Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis: M.B. Harbut, et al.; PNAS 112, 4453 (2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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