Adipogen/Auranofin/AG-CR1-3611-M025/25 mg
商品编号：
AG-CR1-3611-M025
品牌：
Adipogen Inc
市场价：
¥700.00
美元价：
420.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 1-Thio-β-D-glucopyranosatotriethylphosphinegold-2,3,4,6-tetra-acetate;NSC321521;SKF39162 |
| ProductType | Chemical |
| Properties | |
| Formula | C20H34AuO9PS |
| MW | 678.5 |
| MerckIndex | 14:878 |
| CAS | 34031-32-8 |
| RTECS | MD6500000 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOor100%ethanol.Insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | AUJRCFUBUPVWSZ-XTZHGVARSA-M |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anti-inflammatoryandanti-arthriticagent.RepressestheactivationoftheNLRP3/IL-1βpathway.
- Inhibitorof5-lipoxygenaseinhumanneutrophils,IKBkinase(IKK)bymodifyingCys-179oftheIKKβsubunit5.
- Potentthioredoxinreductase(TrxR)inhibitor.Inducesmitochondrialmembranepermeabilitytransition.
- Anti-cancercompoundwithanti-proliferativeactivity.Showntoinduceapoptosisandnecrosis.
- STAT3andtelomeraseactivityinhibitor.
- Proteasomaldeubiquitinaseinhibitor.
- Antibiotic,antiviralandantiparasiticcompound.
- Immunosuppressive.
ProductReferences
- Auranofin.Neworalgoldcompoundfortreatmentofrheumatoidarthritis:A.E.Finkelstein,etal.;Ann.Rheum.Dis.35,251(1976)
- Inhibitionofalveolarmacrophage5-lipoxygenasemetabolismbyauranofin:M.Peters-Golden&C.Shelly;Biochem.Pharmacol.38,1589(1989)
- GoldcompoundauranofininhibitsIkappaBkinase(IKK)bymodifyingCys-179ofIKKbetasubunit:K.I.Jeon,etal.;Exp.Mol.Med.35,61(2003)
- Inhibitionofthioredoxinreductasebyauranofininducesapoptosisincisplatin-resistanthumanovariancancercells:C.Marzano,etal.;FreeRADIc.Biol.Med.42,872(2007)
- Auranofin,animmunosuppressivedrug,inhibitsMHCclassIandMHCclassIIpathwaysofantigenpresentationindendriticcells:S.Han,etal.;Arch.Pharm.Res.31,370(2008)
- Thegoldcompoundauranofininducesapoptosisofhumanmultiplemyelomacellsthroughbothdown-regulationofSTAT3andinhibitionofNF-κBactivity:A.Nakaya,etal.;Leuk.Res.35,243(2011)
- TheBIOLOGicalactivityofauranofin:implicationsfornoveltreatmentofdiseases:J.M.Madeira,etal.;Inflammopharmacology20,297(2012)(Review)
- Antiproliferativeeffectofgold(I)compoundauranofinthroughinhibitionofSTAT3andtelomeraseactivityinMDA-MB231humanbreastcancercells:N.H.Kim,etal.;BMBRep.46,59(2013)
- Drugrepositioning:auranofinasaProspectiveantimicrobialagentforthetreatmentofseverestaphylococcalinfections:M.I.Cassetta,etal.;Biometals27,787(2014)
- Suppressionofthepro-inflammatoryNLRP3/interleukin-1βpathwayinmacrophagesbythethioredoxinreductaseinhibitorauranofin:E.Isakov,etal.;Biochim.Biophys.Acta1840,3153(2014)
- Clinicallyusedantirheumaticagentauranofinisaproteasomaldeubiquitinaseinhibitorandinhibitstumorgrowth:M.Liu,etal.;Oncotarget5,5453(2014)
- AuranofininducesapoptosisandnecrosisinHeLacellsviaoxidativestressandglutathionedepletion:B.R.You,etal.;Mol.Med.Rep.11,1428(2015)
- Auranofin:repurposinganolddrugforagoldennewage:C.Roder&M.J.Thomson;DrugsR.D.15,13(2015)(Review)
- Auranofinexertsbroad-spectrumbactericidalactivitiesbytargetingthiol-redoxhomeostasis:M.B.Harbut,etal.;PNAS112,4453(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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