Adipogen/Atorvastatin calcium salt/SYN-3020-M001/1 mg
商品编号：
SYN-3020-M001
品牌：
Adipogen Inc
市场价：
¥1080.00
美元价：
648.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Lipitor |
| Product Type | Chemical |
| Properties | |
| Formula | (C33H34FN2O5)2 . Ca |
| MW | 1115.2 . 40.1 |
| CAS | 134523-03-8 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg l)="" in="" ethanol.=""> |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: HMG-CoA reductase | Kinase Group: N/A | Substrate: N/A Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | XUKUURHRXDUEBC-KAYWLYCHSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Atorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol. Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels increases hepatic uptake of cholesterol and reduces plasma cholesterol levels. IC(50) values are in the low nanomolar range with cytotoxicity values being largely in the low micromolar range.
Product References
- Update on statins: 2003: C.J. Vaughan & A.M. Gotto; Circulation 110, 886 (2004)
- Atorvastatin inhibits inflammatory hypernociception: T. Santodomingo-Garzón, et al.; Br. J. Pharmacol. 149, 14 (2006)
- Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion: N.A. Turner, et al.; J. Cardiovasc. Pharmacol. 50, 458 (2007)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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