Adipogen/AT9283/SYN-1011-M050/50 mg
商品编号：
SYN-1011-M050
品牌：
Adipogen Inc
市场价：
¥15980.00
美元价：
9588.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AT-9283 |
| ProductType | Chemical |
| Properties | |
| Formula | C19H23N7O2 |
| MW | 381.4 |
| CAS | 896466-04-9 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSOorethanol. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:AuroraA|KinaseGroup:Other|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | LOLPPWBBNUVNQZ-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Aurorakinasesplayakeyroleintheregulationofmitosisandinrecentyearshavebecomeattractivetargetsforthetreatmentofcancer.AT9283isapowerfulinhibitorofAuroraAandBkinasesaswellasseveralotherimportantkinasesincludingJAK2andAbl(T315I).AT9283hasalsobeenshowneffectiveinmouisexenograftmodelsandhasbeenstudiedasapossIBLeclinicalcandidate.EffectiveIC(50)dosesforAurorakinasesareinthelow2-3nMrange,andinhibitionofanumberofotherkinasesincludingJAK2hasbeenreportedat1-10nM.
ProductReferences
- Fragment-baseddiscoveryofthepyrazol-4-ylurea(AT9283),amultitargetedkinaseinhibitorwithpotentaurorakinaseactivity:S.Howard,etal.;J.Med.Chem.52,379(2009)
- Discoveryanddevelopmentofaurorakinaseinhibitorsasanticanceragents:J.R.Pollard&M.Mortimore;J.Med.Chem.52,2629(2009)
- Design,synthesis,quantumchemicalstudiesandBIOLOGicalactivityevaluationofpyrazole-benzimidazolederivativesaspotentAuroraA/Bkinaseinhibitors:Y.Zheng,etal.;Bioorg.Med.Chem.Lett.23,3523(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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