Adipogen/Asiatic acid/AG-CN2-0400-M005/5 mg
商品编号：
AG-CN2-0400-M005
品牌：
Adipogen Inc
市场价：
¥800.00
美元价：
480.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2α,23-Dihydroxyursolicacid;Dammarolicacid;NSC166063 |
| ProductType | Chemical |
| Properties | |
| Formula | C30H48O5 |
| MW | 488.7 |
| CAS | 464-92-6 |
| Source/HostChemicals | IsolatedfromCentellaasiatica. |
| PurityChemicals | ≥95%(NMR) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSO,ethanolordimethylformamide.Sparinglysolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | JXSVIVRDWWRQRT-UYDOISQJSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. Protectfrommoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Apoptosisinducer[1,3].
- Cellcyclearrestinducer[1].
- Anticancercompound[1,5]
- Antioxidant.Hepatoprotective[2].InhibitsTGF-β/Smad-mediatedfibrogenesis[12].
- Stimulateswoundhealing[4].
- Anti-diabetic.Glycogenphosphorylaseinhibitor[6].
- Neuroprotective[13].Modulatesmultipletargetsassociatedwithamyloid-βprecursorproteinprocessingandamyloid-βproteinclearance.DownregulatesBACE1andincreasesADAM10maturation[7].
- Anti-hyperglycemiccompound[8,14].
- Anti-inflammatoryandantinociceptivecompound[9].
- Antiangiogenic[10].
- Acetylcholinesterase(AChE)inhibitor[11].
- PPARγinhibitorthroughaC/EBPβ-independentmechanisms[15].
- Anti-osteoporotic.InhibitsADIpogenicdifferentiationofbonemarrowstromalcells(BMSC)[15].
ProductReferences
- Asiaticacid,atriterpene,inducesapoptosisandcellcyclearrestthroughactivationofextracellularsignal-regulatedkinaseandp38mitogen-activatedproteinkinasepathwaysinhumanbreastcancercells:Y.L.Hsu,etal.;J.Pharmacol.Exp.Ther.313,333(2005)
- Mechanismunderlyingmitochondrialprotectionofasiaticacidagainsthepatotoxicityinmice:J.Gao,etal.;J.Pharm.Pharmacol.58,227(2006)
- DisruptionoftheendoplasmicreticulumandincreasesincytoplasmiccalciumareearlyeventsincelldeathinducedbythenaturaltriterpenoidAsiaticacid:G.M.Gurfinkel,etal.;Apoptosis11,1463(2006)
- Structure-activityrelationshipstudyofasiaticacidderivativesfornewwoundhealingagent:B.S.Jeong;Arch.Pharm.Res.29,556(2006)
- Asiaticacidinducescoloncancercellgrowthinhibitionandapoptosisthroughmitochondrialdeathcascade:X.L.Tang,etal.;Biol.Pharm.Bull.32,1399(2009)
- SynthesisandBIOLOGicalevaluationofasiaticacidderivativesasinhibitorsofglycogenphosphorylases:L.Zhang,etal.;Chem.Biodivers.6,864(2009)
- WithanolideAandasiaticacidmodulatemultipletargetsassociatedwithamyloid-betaprecursorproteinprocessingandamyloid-betaproteinclearance:S.P.Patil,etal.;J.Nat.Prod.73,1196(2010)
- Asiaticacidpreservesbetacellmassandmitigateshyperglycemiainstreptozocin-induceddiabeticrats:J.Liu,etal.;DiabetesMetab.Res.Rev.26,448(2010)
- Antinociceptiveactivitiesandthemechanismsofanti-inflammationofasiaticAcidinmice:S.S.Huang,etal.;Evid.BasedComplementAlternat.Med.2011,895857(2011)
- Asiaticacidinhibitspro-angiogeniceffectsofVEGFandhumangliomasinendothelialcellculturemodels:C.V.Kavitha,etal.;PLoSOne6,e22745(2011)
- Inhibitoryeffectofasiaticacidonacetylcholinesterase,excitatorypostsynapticpotentialandlocomotoractivity:M.N.Nasir,etal.;Phytomedicine19,311(2012)
- AsiaticacidinhibitsliverfibrosisbyblockingTGF-beta/Smadsignalinginvivoandinvitro:L.X.Tang,etal.;PLoSOne7,e31350(2012)
- Asiaticacidattenuatesinfarctvolume,mitochondrialdysfunction,andmatrixmetalloproteinase-9inductionafterfocalcerebralischemia:K.Y.Lee,etal.;Stroke43,1632(2012)
- Efficacyofasiaticacid,apentacyclictriterpeneonattenuatingthekeyenzymesactivitiesofcarbohydratemetabolisminstreptozotocin-induceddiabeticrats:V.Ramachandran&R.Saravanan;Phytomedicine20,230(2013)
- AsiaticAcidInhibitsAdipogenicDifferentiationofBoneMarrowStromalCells:Z.W.Li,etal.;CellBiochem.Biophys.68,437(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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