Adipogen/Ascomycin (high purity)/AG-CN2-0420-M005/5 mg
商品编号：
AG-CN2-0420-M005
品牌：
Adipogen Inc
市场价：
¥800.00
美元价：
480.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Immunomycin;FK520;AnalogofFK-506;FR-900520;L-683590;NSC106410;WS7238A |
| ProductType | Chemical |
| Properties | |
| Formula | C43H69NO12 |
| MW | 792.0 |
| CAS | 104987-12-4 |
| RTECS | CI7570000;KD4185000 |
| Source/HostChemicals | IsolatedfromStreptomycessp.. |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOorethanol. |
| Identity | DeterminedbyMSandIR. |
| InChiKey | ZDQSOHOQTUFQEM-VZQNCADUSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Macrolideantibiotic.EthylanalogofFK506[1,2].
- Strongimmunosuppressant.BindstotheFK-506-bindingproteinFKBP12.Thiscomplexinhibitscalcineurin(proteinphosphatase2B(PP2B))[2-4,8].
- SuppressestheproductionofThelpertype1(Th1)(interferonandIL-2)andTh2(IL-4andIL-10)cytokinesinTlymphocytesandpreferentiallyinhibitstheactivationofmastcells[5-7].
- Anti-inflammatory.Usedfortopicaltreatmentofinflammatoryskindiseases[5,6].
- Potentlyinhibitsanti-IgE-inducedhistamineandcytokinereleaseandreducesIgE-dependentp38MAPKactivationinhumanbasophils.Inhibitsbasophildegranulationattheinitialphaseofallergicskinreactions[7,8].
- Antifungal[1].
- Antimalariacompound[9].
- Anticonvulsant(antiepileptic)[10,11].
ProductReferences
- Ascomycin,anantifungalantibiotic:T.Arai,etal.;J.Antibiot.15,231(1962)
- IdentityofimmunosuppressantFR-900520withascomycin:M.Morisaki,etal.;J.Antibiot.45,126(1992)
- ComparisonofFK-506,rapamycin,ascomycin,andcyclosporineinmousemodelsofhost-versus-graftdiseaseandheterotopichearttransplantation:K.W.Mollison,etal.;Ann.N.Y.Acad.Sci.685,55(1993)
- FR-900520andFR-900523,novelimmunosuppressantsisolatedfromaStreptomyces.II.Fermentation,isolationandphysico-chemicalandBIOLOGicalcharacteristics:H.Hatanaka,etal.;J.Antibiot.(Tokyo)41,1592(1988)
- Ascomycins:promisingagentsforthetreatmentofinflammatoryskindiseases:C.Paul,etal.;ExpertOpin.Investig.Drugs9,69(2000)
- Ascomycin:anadvanceinthemanagementofatopicdermatitis:C.E.Griffiths;Br.J.Dermatol.144,679(2001)
- Theascomycinmacrolactampimecrolimus(Elidel,SDZASM981)isapotentinhibitorofmediatorreleasefromhumandermalmastcellsandperipheralbloodbasophils:T.Zuberbier,etal.;J.AllergyClin.Immunol.108,275(2001)
- CalcineurinantagoNISTsdifferentiallyaffectmediatorsecretion,p38mitogen-activatedproteinkinaseandextracellularsignal-regulatedkinasesfromimmunologicallyactivatedhumanbasophils:K.E.Plath,etal.;Clin.Exp.Allergy33,342(2003)
- AntimalarialeffectsofmacrolactonesrelatedtoFK520(ascomycin)areindependentoftheimmunosuppressivepropertiesofthecompounds:P.Monaghan,etal.;J.Infect.Dis. 191,1342(2005)
- Anticonvulsanteffectofthecalcineurininhibitorascomycinonseizuresinducedbypicrotoxinmicroperfusionintherathippocampus:A.Vazquez-Lopez,etal.;Pharmacol.Biochem.Behav.84,511(2006)
- AscomycinandFK506:pharmacologyandtherapeuticpotentialasanticonvulsantsandneuroprotectants:G.Sierra-Paredes&G.Sierra-Marcuno;CNSNeurosci.Ther.14,36(2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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