Adipogen/AS-703026/SYN-1190-M010/10 mg
商品编号：
SYN-1190-M010
品牌：
Adipogen Inc
市场价：
¥2600.00
美元价：
1560.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AS703026 |
| ProductType | Chemical |
| Properties | |
| Formula | C15H15FIN3O3 |
| MW | 431.2 |
| CAS | 1236699-92-5 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO.Slightlysoluble(<1mg l)="" in="" ethanol.=""> |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:MEK1-MEK2|KinaseGroup:STE|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | VIUAUNHCRHHYNE-JTQLQIEISA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
AS703026isanovel,selective,non-competitive,orallybioavailableMEK1/2inhibitorwithexperimentalIC(50)valuesof5-11nM.Inuseonmultiplemyelomacells(MM),AS703026inhibitedgrowthandsurvivalofMMcellsandcytokine-inducedosteoclastdifferentiationmorepotently(~10X)thanAZD6244.InhibitionofproliferationinducedbyAS703026wasmediatedbyG0-G1cellcyclearrestandwasaccompaniedbyreductionofMAFoncogeneexpression.AS703026furtherinducedapoptosisviacaspase3andPolyADPribosepolymerase(PARP)cleavageinMMcells,bothinthepresenceorabsenceofbonemarrowstromalcells(BMSCs).Importantly,AS703026sensitizedMMcellstoabroadspectrumofconventional(dexamethasone,melphalan),noveloremerging(lenalidomide,perifosine,bortezomib,rapamycin)anti-MMtherapies.SignificanttumourgrowthreductioninAS703026-vs.vehicle-treatedmicebearingH929MMxenografttumourscorrelatedwithdownregulatedpERK1/2,inducedPARPcleavage,anddecreasedmicrovesselsinvivo.Moreover,AS703026(<200nm) was="" cytotoxic="" against="" the="" majority="" of="" tumour="" cells="" tested="" from="" patients="" with="" relapsed="" and="" refractory="" mm="" (84%),="" regardless="" of="" mutational="" status="" of="" ras="" and="" braf="" genes.="" importantly,="" bmsc-induced="" viability="" of="" mm="" patient="" cells="" was="" similarly="" blocked="" within="" the="" same="" dose="">
ProductReferences
- BlockadeoftheMEK/ERKsignallingcascadebyAS703026,anovelselectiveMEK1/2inhibitor,inducespleiotropicanti-myelomaactivityinvitroandinvivo:K.Kim,etal.;Br.J.Haematol.149,537(2010)
- MEK1/2inhibitorsAS703026andAZD6244maybepotentialtherapiesforKRASmutatedcolorectalcancerthatisresistanttoEGFRmonoclonalantibodytherapy:J.Yoon,etal.;J.CancerRes.71,445(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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