Adipogen/Arglabin/AG-CN2-0458-M001/1 mg
商品编号：
AG-CN2-0458-M001
品牌：
Adipogen Inc
市场价：
¥1500.00
美元价：
900.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Arglabine |
| Product Type | Chemical |
| Properties | |
| Formula | C15H18O3 |
| MW | 246.3 |
| CAS | 84692-91-1 |
| Source/Host Chemicals | Semi-synthetic from parthenolide (AG-CN2-0455), which is isolated from Magnolia grandiflora. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water. |
| InChi Key | UVJYAKBJSGRTHA-CUZKYEQNSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Anticancer compound.
- Farnesyltransferase inhibitor.
- Potent anti-inflammatory agent.
- NF-κB inhibitor.
- Inflammasome inhibitor.
- Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.
Product References
- In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall: C. Bottex-Gauthier, et al.; Biotechnol. Ther. 4, 77 (1993)
- Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase: T.E. Shaikenov, et al.; Oncol. Rep. 8, 173 (2001)
- Biomimetic semisynthesis of arglabin from parthenolide: J.D. Zhai, et al.; JOC 77, 7103 (2012)
- Synthesis and biological evaluation of antitumor-active arglabin derivatives: R. Csuk, et al.; Arch Pharm. 345, 215 (2012)
- Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells: Q.Q. Jia, et al.; Molecules 18, 13061 (2013)
- Hemisynthesis of a naturally occurring clinically significant antitumor arglabin from ludartin: S.H. Lone & K.A. Bhat; THL 56, 1908 (2015)
- Anti-Inflammatory and antiatherogenic effects of the NLRP3 Inflammasome inhibitor Arglabin in ApoE2.Ki mice fed a high-fat diet: A. Abderrazak, et al.; Circulation 131, 1061 (2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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