Adipogen/Apicidin/AG-CN2-0087-M005/5 mg
商品编号：
AG-CN2-0087-M005
品牌：
Adipogen Inc
市场价：
¥4000.00
美元价：
2400.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl];OSI-2040 |
| ProductType | Chemical |
| Properties | |
| Formula | C34H49N5O6 |
| MW | 623.8 |
| CAS | 183506-66-3 |
| Source/HostChemicals | IsolatedfromfungusFusariumsp. |
| PurityChemicals | ≥98%(HPLC,TLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinethanolorDMSO. |
| InChiKey | JWOGUUIOCYMBPV-LQJYRIKDSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antiprotozoal[1].
- Potentinhibitorofhistonedeacetylase(HDAC)[1,2].
- Inhibitsproliferation[2,3].
- InducescellcyclearrestattheG1phase[2].
- InduceshyperacetylationofhistoneH4[5].
- Apoptosisinducer[4,8,9].
- Potentanti-angiogeniccompound[5-7].
- DecreasesHIF-1αproteinlevelsandtranscriptionalactivityinhumanandmousetumorcelllines[3].
- Autophagyinducerinoralsquamouscellcarcinoma(OSCC)cells[8].
- Promoteseitherself-renewalordifferentiationofembryonicstemcells[10].
ProductReferences
- Apicidin:anovelantiprotozoalagentthatinhibitsparasitehistonedeacetylase:S.J.Darkin-Rattray,etal.;PNAS93,13143(1996)
- Apicidin,ahistonedeacetylaseinhibitor,inhibitsproliferationoftumorcellsviainductionofp21WAF1/Cip1andgelsolin:J.W.Han,etal.;CancerRes.60,6068(2000)
- Transcriptionalactivationofp21(WAF1/CIP1)byapicidin,anovelhistonedeacetylaseinhibitor:J.S.Kim,etal.;BBRC281,866(2001)
- Apicidin,ahistonedeacetylaseinhibitor,inducesapoptosisandFas/Fasligandexpressioninhumanacutepromyelocyticleukemiacells:S.H.Kwon,etal.;J.Biol.Chem.277,2073(2002)
- Apicidin,ahistonedeacetylaseinhibitor,inducesdifferentiationofHL-60cells:J.Hong,etal.;CancerLett.189,197(2003)
- RegulationoftheHIF-1alphastabilitybyhistonedeacetylases:S.H.Kim,etal.;Oncol.Rep.17,647(2007)
- Apicidin,anovelhistonedeacetylaseinhibitor,hasprofoundanti-growthactivityinhumanendometrialandovariancancercells:T.Ueda,etal.;Int.J.Mol.Med.19,301(2007)
- Apicidin,ahistonedeaceylaseinhibitor,inducesbothapoptosisandautophagyinhumanoralsquamouscarcinomacells:M.Y.Ahn,etal.;Oral.Oncol.47,1032(2011)
- Apicidininducesendoplasmicreticulumstress-andmitochondrialdysfunction-associatedapoptosisviaphospholipaseCγ1-andCa(2+)-dependentpathwayinmouseNeuro-2aneuroblastomacells:J.H.Choi,etal.;Apoptosis17,1340(2012)
- HistoneDeacetylaseInhibitorsinCellPluripotency,Differentiation,andReprogramming:A.Kretsovali,etal.;StemCellsInt.2012,1(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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