Adipogen/Anthralin/CDX-D0308-G001/1 g
商品编号：
CDX-D0308-G001
品牌：
Adipogen Inc
市场价：
¥1420.00
美元价：
852.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Dithranol; 1,8-Dihydroxyanthrone; Anthracene-1,8,9-triol; NSC 43970; NSC 629313 |
| Product Type | Chemical |
| Properties | |
| Formula | C14H10O3 |
| MW | 226.2 |
| CAS | 1143-38-0 |
| RTECS | CB8927000 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Faint yellow to yellow powder. |
| Solubility | Soluble in acetone. |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | NUZWLKWWNNJHPT-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Anthralin is a leukotriene biosynthesis inhibitor. It inhibits LTB4 ω-oxidation and disrupts mitochondria function. Anthralin is used in the treatment of psoriasis, as a fungicide, in the treatment of ringworm infections and in chronic dermatoses. It accumulates in mitochondria where it interferes with the supply of energy to the cell, probably by the oxidation of dithranol releasing free radicals. This impedes DNA replication and so slows the excessive cell division that occurs in psoriatic plaques. Numerous studies have demonstrated anti-proliferative and anti-inflammatory effects of anthralin on psoriatic and normal skin. It is also used as matrix substance for MALDI-MS (matrix-assisted laser desorption ionization MS).
Product References
(1) R.E. Ashton, et al.; J. Am. Acad. Dermatol. 9, 173 (1983) | (2) J.M. Schröder; J. Invest. Dermatol. 87, 624 (1986) | (3) C.E. Orfanos, et al.; Drugs 34, 459 (1987) (Review) | (4) L. Kemeny, et al.; Skin Pharmacol. 3, 1 (1990) | (5) K. Müller; Biochem. Pharmacol. 53, 1215 (1997) (Review) | (6) K. Pavithran; Indian J. Dermatol. Venereol. Leprol. 67, 104 (2001) | (7) C.H. Le, et al.; Anal. Chem. 84, 8391 (2012) | (8) C. Ronpirin & T. Tencomnao; Genet. Mol. Res. 11, 412 (2012) | (9) S.E. George, et al.; J. Pharm. Pharmacol. 65, 552 (2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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