Adipogen/Amlexanox/AG-CR1-3579-M050/50 mg
商品编号：
AG-CR1-3579-M050
品牌：
Adipogen Inc
市场价：
¥4000.00
美元价：
2400.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid; AA 673; Amoxanox; CHX 3673 |
| Product Type | Chemical |
| Properties | |
| Formula | C16H14N2O4 |
| MW | 298.3 |
| CAS | 68302-57-8 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or dimethylformamide. |
| InChi Key | SGRYPYWGNKJSDL-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Antiallergic [1,2].
- Anti-inflammatory [2].
- Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release [3, 5].
- Binds to HSP90. Inhibits C-terminal chaperone activity [4].
- Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the synthesis of functional full-length proteins in an efficient manner [6].
- Selective inhibitor of TANK-binding Kinase 1 (TBK1) and IKKε. Reversibly lowers weight and improves insulin sensitivity and reduces inflammation and attenuated hepatic steatosis in obese mices without affecting food intake [7].
Product References
- Inhibition by amoxanox (AA-673) of the immunologically, leukotriene D4- or platelet-activating factor-stimulated bronchoconstriction in guinea pigs and rats: T. Saijo, et al.; Int. Arch. Allergy Appl. Immunol. 77, 315 (1985)
- Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase: H. Makino, et al.; Int. Arch. Allergy Appl. Immunol. 82, 66 (1987)
- Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro: M. Landriscina, et al.; J. Biol. Chem. 275, 32753 (2000)
- Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox: M. Okada, et al.; Biochem. J. 374, 433 (2003)
- Molecular level interactions of S100A13 with amlexanox: inhibitor for formation of the multiprotein complex in the nonclassical pathway of acidic fibroblast growth factor: S.G. Rani, et al.; Biochemistry 49, 2585 (2010)
- Rescue of nonsense mutations by amlexanox in human cells: S. Gonzalez-Hilarion, et al.; Orphanet. J. Rare Dis. 7, 58 (2012)
- An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice: S.M. Reilly, et al.; Nat. Med. 19, 313 (2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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