Adipogen/Amlexanox/AG-CR1-3579-M010/10 mg
商品编号：
AG-CR1-3579-M010
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylicacid;AA673;Amoxanox;CHX3673 |
| ProductType | Chemical |
| Properties | |
| Formula | C16H14N2O4 |
| MW | 298.3 |
| CAS | 68302-57-8 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOordimethylformamide. |
| InChiKey | SGRYPYWGNKJSDL-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antiallergic[1,2].
- Anti-inflammatory[2].
- AntagonizestheangiogenicandmitogenicactivityofFGF-1throughS100A13.InhibitsFGF-1release[3,5].
- BindstoHSP90.InhibitsC-terminalchaperoneactivity[4].
- Inducesanincreaseinnonsense-containingmRNAsamountintreatedcells,leADIngtothesynthesisoffunctionalfull-lengthproteinsinanefficientmanner[6].
- SelectiveinhibitorofTANK-bindingKinase1(TBK1)andIKKε.ReversIBLylowersweightandimprovesinsulinsensitivityandreducesinflammationandattenuatedhepaticsteatosisinobesemiceswithoutaffectingfoodintake[7].
ProductReferences
- Inhibitionbyamoxanox(AA-673)oftheimmunologically,leukotrieneD4-orplatelet-activatingfactor-stimulatedbronchoconstrictioninguineapigsandrats:T.Saijo,etal.;Int.Arch.AllergyAppl.Immunol.77,315(1985)
- Mechanismofactionofanantiallergicagent,amlexanox(AA-673),ininhibitinghistaminereleasefrommastcells.AccelerationofcAMPgenerationandinhibitionofphosphodiesterase:H.Makino,etal.;Int.Arch.AllergyAppl.Immunol.82,66(1987)
- AmlexanoxreversiblyinhibitscellmigrationandproliferationandinducestheSrc-dependentdisassemblyofactinstressfibersinvitro:M.Landriscina,etal.;J.Biol.Chem.275,32753(2000)
- Hsp90isadirecttargetoftheanti-allergicdrugsdisodiumcromoglycateandamlexanox:M.Okada,etal.; Biochem.J.374,433(2003)
- MolecularlevelinteractionsofS100A13withamlexanox:inhibitorforformationofthemultiproteincomplexinthenonclassicalpathwayofacidicfibroblastgrowthfactor:S.G.Rani,etal.;Biochemistry49,2585(2010)
- Rescueofnonsensemutationsbyamlexanoxinhumancells:S.Gonzalez-Hilarion,etal.;Orphanet.J.RareDis.7,58(2012)
- AninhibitoroftheproteinkinasesTBK1andIKK-εimprovesobesity-relatedmetabolicdysfunctionsinmice:S.M.Reilly,etal.;Nat.Med.19,313(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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