Adipogen/AMG-47a/SYN-1007-M100/100 mg
商品编号：
SYN-1007-M100
品牌：
Adipogen Inc
市场价：
¥61560.00
美元价：
36936.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AMG47a |
| ProductType | Chemical |
| Properties | |
| Formula | C29H28F3N5O2 |
| MW | 535.6 |
| CAS | 882663-88-9 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:LIMK|KinaseGroup:TKL|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | DVRSTRMZTAPMKO-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Thelymphocyte-specifickinase(Lck)isacytoplasmictyrosinekinaseoftheSrcfamilyexpressedinTcellsandnaturalkiller(NK)cells.GeneticevidenceinbothmiceandhumansdemonstratesthatLckkinaseactivityiscriticalforsignalingmediatedbytheTcellreceptor(TCR),whichleadstonormalTcelldevelopmentandactivation.SelectiveinhibitionofLckisexpectedtoofferanewtherapyforthetreatmentofT-cell-mediatedautoimmuneandinflammatorydisease.AMG-47isoneoftwooptimizedchemicalcompoundsthathasbeenshowntobeextremelyeffectiveinvivoandinvitroininhibitingLckaswellasanumberofotherreceptortyrosinekinases.Inananti-CD3/IL-2mousemodelsystemAMG-47hasbeenshowntobeeffectiveininhibitingtheLckmediatedanti-inflammatoryactivity(ED5011mg/kg;630nM)invivo.Inmultipleotherinvitroassays,AMG-47exhibitssubnanomolarinhibitionagainstLck,andlow(<10nm) inhibition="" against="" other="" hard="" to="" inhibit="" kinases="" such="" as="" kdr="" and="" src="" and="" mapk="" α="" (p38α).="" moreover="" at="" slightly="" higher="" doses="" but="" well="" under="" 10µm,="" amg-47="" effectively="" inhibits="" the="" jnk="" family="" of="" kinases="" including="" tyk2="" at="" ~="">
ProductReferences
- Discoveryofaminoquinazolinesaspotent,orallybioavailableinhibitorsofLck:synthesis,SAR,andinvivoanti-inflammatoryactivity:E.F.DiMauro,etal.;J.Med.Chem.49,5671(2006)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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