Adipogen/Alternariol/BVT-0465-M005/5 mg
商品编号：
BVT-0465-M005
品牌：
Adipogen Inc
市场价：
¥3480.00
美元价：
2088.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AOH;NSC638263;3,4",5-Trihydroxy-6"-methyldibenzo-α-pyrone |
| ProductType | Chemical |
| Properties | |
| Formula | C14H10O5 |
| MW | 258.2 |
| CAS | 641-38-3 |
| RTECS | HP8757000 |
| Source/HostChemicals | IsolatedfromAlternariasp. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Lightbrownsolid. |
| Solubility | SolubleinDMSO(20mg/ml)orDMF.Slightlysolubleinacetone(1mg/ml). |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | CEBXXEKPIIDJHL-UHFFFAOYSA-N |
| Smiles | OC1=CC(C2=C(C)C=C(O)C=C2O3)=C(C(O)=C1)C3=O |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat+4°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
- Mycotoxin.
- Phytotoxin.
- Showscytotoxic,teratogenic,mutagenicandgenotoxicpropertiesbyDNAintercalation.
- InducesseveraltypesofDNAdamage,includingoxidativeDNAdamage,single-strandedDNAbreaks(SSB)anddouble-strand,throughAOH-inducedROSproductionandinteractionwithDNAtopoisomerase.
- InhibitstheactivityoftopoisomeraseIIαinmammaliancells.
- InducescellgrowtharrestinG2/Mphase.
- GSK-3βinhibitor(sub-μMIC50values).
- Antiviralactivity(herpessimplex).
- HepatitisCNS3-4Aproteaseinhibitor.
- InducescytochromeP4501A1expressionandapoptosisinmousehepatomacells.
ProductReferences
- Studiesinthebiochemistryofmicro-organisms.90.Alternariolandalternariolmonomethylether,metabolicproductsofAlternariatenuis:H.Raistrick,etal.;Biochem.J.55,421(1953)
- Alternariol,adibenzopyronemycotoxinofAlternariaspp.,isanewphotosensitizingandDNAcross-linkingagent:F.DiCosmo&N.A.Straus;Experientia41,1188(1985)
- EvaluationofalternariolandalternariolmethyletherformutagenicactivityinSalmonellatyphimurium:V.M.Davis&M.E.Stack;Appl.Environ.Microbiol.60,3901(1994)
- AlternariolactsasatopoisomerasepoisonpreferentiallyaffectingtheIIαisoform.:M.Fehr,etal.;Mol.Nutr.FoodRes.53,441(2009)
- MechanismofAlternariolmonomethylether-inducedmitochondrialapoptosisinhumancoloncarcinomacells:F.Bensassi,etal.;Toxicology290,230(2011)
- HeptaketideswithantiviralactivityfromthreeendolichenicfungalstrainsNigrosporasp.,Alternariasp.andPhialophorasp.:J.-W.He,etal.;Fitoterapia83,1087(2012)
- Alternariol:D.Siegel,etal.;ActaCrystallogr.Sec.EStruct.Rep.Online66,o1366(2010)
- TheFungalPhytotoxinAlternariol9-MethylEtherandSomeofItsSyntheticAnaloguesInhibitthePhotosyntheticElectronTransportChain:A.Demuner,etal.;J.Nat.Prod.76,2234(2013)
- ModulationofthecellularredoxstatusbytheAlternariatoxinsalternariolandalternariolmonomethylether:C.Tiessen,etal.;Toxicol.Lett.216,23(2013)
- MycotoxinsfromAlternaria:toxicologicalimplications:C.Dall"Asta,etal.;Adv.Mol.Toxicol.8,107(2014)
- ImpactofAlternariatoxinsonCYP1A1expressionindifferenthumantumorcellsandrelevanceforgenotoxicity:G.Pahlke,etal.;Toxicol.Lett.240,93(2016)
- Marinefungiasproducersofbenzocoumarins,anewclassofinhibitorsofglycogen-synthase-kinase3β:J.Wiese,etal.;Mar.Drugs2016,14(2016)
- Involvementofp38MAPK-ATF2signalingpathwayinalternariolinducedDNApolymeraseβexpression:Z.Jimin,etal.;Oncol.Lett.12,675(2016)
- AlternariolinducetoxicityviacelldeathandmitochondrialdamageonCaco-2cells:C.Fernandez-Blanco,etal.;FoodChem.Toxicol.88,32(2016)
- MechanismsofActionandToxicityoftheMycotoxinAlternariol:AReview:A.Solhaug,etal.;BasicClin.Pharmacol.Toxicol.119,533(2016)
- TheAlternariaalternataMycotoxinalternariolsuppresseslipopolysaccharide-inducedinflammation:S.Grover&C.B.Lawrence;Int.J.Mol.Sci.2017,18(2017)
- ImpactofphaseImetabolismonuptake,oxidativestressandgenotoxicityoftheemergingmycotoxinalternariolanditsmonomethyletherinesophagealcells:C.Tiessen,etal.;Arch.Toxicol.91,1213(2017)
- DualeffectivenessofalternariabutnotfusariummycotoxinsagainsthumantopoisomeraseIIandbacterialgyrase:K.Jarolim,etal.;Arch.Toxicol.91,2007(2017)
- GeNISTeinanddelphinidinantagonizethegenotoxiceffectsofthemycotoxinalternariolinhumancoloncarcinomacells:G.Aichinger,etal.;Mol.Nutr.FoodRes.2017,61(2017)
- Nonsteroidalmycotoxinalternariolisafullandrogenagonistintheyeastreporterandrogenbioassay:S.Stypula-Trebas,etal.;Environ.Toxicol.Pharmacol.55,208(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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