Adipogen/Alsterpaullone/AG-CR1-0036-M005/5 mg
商品编号：
AG-CR1-0036-M005
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one |
| Product Type | Chemical |
| Properties | |
| Formula | C16H11N3O3 |
| MW | 293.3 |
| CAS | 237430-03-4 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Yellow to brown powder. |
| Solubility | Soluble in DMSO; insoluble in water or 100% ethanol. |
| Identity | Determined by IR, 1H-NMR and 13C-NMR. |
| InChi Key | OLUKILHGKRVDCT-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Potent CDK1/cyclin B (IC50 = 35 nM) inhibitor [1].
- Anti-tumor compound [1]
- Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E (IC50 = 200 nM), CDK5/p25 (IC50 = 40 nM), CDK5/p35 (IC50 = 40 nM) [2, 4].
- GSK-3β (glycogen synthase kinase-3β) inhibitor [2, 3].
- Apoptosis inhibitor [6, 7].
- Apoptosis inducer [5].
- Angiogenesis inhibitor [8].
Product References
- Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity: C. Schultz, et al.; J. Med. Chem. 42, 2909 (1999)
- Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25: M. Leost, et al.; Eur. J. Biochem. 267, 5983 (2000)
- Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor: M. Knockaert, et al.; J. Biol. Chem. 277, 25493 (2002)
- The specificities of protein kinase inhibitors: an update: J. Bain, et al.; Biochem. J. 371, 199 (2003)
- Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential: T. Lahusen, et al.; Mol Carcinog 36, 183 (2003)
- Thapsigargin-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells: T. Takadera, et al.; Neurosci. Lett. 408, 124
- Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells: T. Takadera, et al.; Cell. Mol. Neurobiol. 30, 863 (2010)
- Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro: S. Zahler, et al.; Angiogenesis 13, 239 (2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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