Adipogen/Alsterpaullone/AG-CR1-0036-M001/1 mg
商品编号：
AG-CR1-0036-M001
品牌：
Adipogen Inc
市场价：
¥1100.00
美元价：
660.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one |
| ProductType | Chemical |
| Properties | |
| Formula | C16H11N3O3 |
| MW | 293.3 |
| CAS | 237430-03-4 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Yellowtobrownpowder. |
| Solubility | SolubleinDMSO;insolubleinwateror100%ethanol. |
| Identity | DeterminedbyIR,1H-NMRand13C-NMR. |
| InChiKey | OLUKILHGKRVDCT-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentCDK1/cyclinB(IC50 =35nM)inhibitor[1].
- Anti-tumorcompound[1]
- PotentinhibitorofCDK2/cyclinA,CDK2/cyclinE(IC50=200nM),CDK5/p25(IC50=40nM),CDK5/p35(IC50=40nM)[2,4].
- GSK-3β(glycogensynthasekinase-3β)inhibitor[2,3].
- Apoptosisinhibitor[6,7].
- Apoptosisinducer[5].
- Angiogenesisinhibitor[8].
ProductReferences
- Paullones,aseriesofcyclin-dependentkinaseinhibitors:synthesis,evaluationofCDK1/cyclinBinhibition,andinvitroantitumoractivity:C.Schultz,etal.;J.Med.Chem. 42,2909(1999)
- Paullonesarepotentinhibitorsofglycogensynthasekinase-3betaandcyclin-dependentkinase5/p25:M.Leost,etal.;Eur.J.Biochem. 267,5983(2000)
- IntracellularTargetsofPaullones.Identificationfollowingaffinitypurificationonimmobilizedinhibitor:M.Knockaert,etal.;J.Biol.Chem. 277,25493(2002)
- Thespecificitiesofproteinkinaseinhibitors:anupdate:J.Bain,etal.;Biochem.J. 371,199(2003)
- Alsterpaullone,anovelcyclin-dependentkinaseinhibitor,inducesapoptosisbyactivationofcaspase-9duetoperturbationinmitochondrialmembranepotential:T.Lahusen,etal.;MolCarcinog 36,183(2003)
- Thapsigargin-inducedapoptosiswaspreventedbyglycogensynthasekinase-3inhibitorsinPC12cells:T.Takadera,etal.;Neurosci.Lett.408,124
- Colchicine-inducedapoptosiswaspreventedbyglycogensynthasekinase-3inhibitorsinPC12cells:T.Takadera,etal.;Cell.Mol.Neurobiol.30,863(2010)
- Anti-angiogenicpotentialofsmallmolecularinhibitorsofcyclindependentkinasesinvitro:S.Zahler,etal.;Angiogenesis13,239(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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