Adipogen/Alpelisib/SYN-1230-M010/10 mg
商品编号：
SYN-1230-M010
品牌：
Adipogen Inc
市场价：
¥4760.00
美元价：
2856.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide;BYL719;NVP-BYL719 |
| ProductType | Chemical |
| Properties | |
| Formula | C19H22F3N5O2S |
| MW | 441.5 |
| CAS | 1217486-61-7 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSOorDMF. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:PI3Kalpha|KinaseGroup:LipidKinase|Substrate:Lipid ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | STUWGJZDJHPWGZ-LBPRGKRZSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
SelectivePI3KαinhibitorwithIC50of5nM.HasminimaleffectonotherPI3Kisoforms.Exhibitsfavorablepharmacokineticsandexcellentoralbioavailabilityinanimalmodels.Inxenograftsusingnudemice,itshoweddose-dependenteffectsoftumourinhibition.InaphaseIbstudy,itshowedsynergisticanti-tumoractivitywithendocrinetherapyagainstER+/PIK3CAmutatedbreastcancercells.
ProductReferences
- DiscoveryofNVP-BYL719apotentandselectivephosphatidylinositol-3kinasealphainhibitorselectedforclinicalevaluation:P.Furet,etal.;Bioorg.Med.Chem.Lett.23,3741(2013)
- CharacterizationofthenovelandspecificPI3KαinhibitorNVP-BYL719anddevelopmentofthepatientstratificationstrategyforclinicaltrials:C.Fritsch,etal.;Mol.CancerTher.13,1117(2014)
- APhaseIbStudyofAlpelisib(BYL719),aPI3Kα-specificInhibitor,withLetrozoleinER+/HER2-NegativeMetastaticBreastCancer:I.A.Mayer,etal.;Clin.CancerRes.(Epubaheadofprint)(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
