Adipogen/AICAR/AG-CR1-0061-M100/100 mg
商品编号：
AG-CR1-0061-M100
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 5-Aminoimidazole-4-carboxamide1-β-D-ribofuranoside;Acadesine;AICA-Riboside |
| ProductType | Chemical |
| Properties | |
| Formula | C9H14N4O5 |
| MW | 258.2 |
| MerckIndex | 14:16 |
| CAS | 2627-69-2 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Off-whitesolid. |
| Solubility | Solubleinwater(9mg/ml),DMSOordimethylformamide. |
| Identity | Determinedby1H-NMR. |
| InChiKey | RTRQQBHATOEIAF-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- CellpermeableAMP-activatedproteinkinase(AMPK)activator[1].
- Insulinmimetic[2,10].
- ADIpocytedifferentiationinhibitor[3].
- Apoptosisinducer[4,11].
- PPARαinhibitor[5].
- mTORinhibitor[6].
- P70S6Kinhibitor[6].
- LPS-inducedTNF-αproductioninhibitor[7].
- TORC2phosphorylationinducer[8].
- Anti-inflammatory[9].
- Anti-tumorcompound[12].
- Autophagyinhibitor[13].
- HSP90inhibitor[14].
- Autophagyinducer[15]
ProductReferences
- 5-aminoimidazole-4-carboxamideribonucleoside.AspecificmethodforactivatingAMP-activatedproteinkinaseinintactcells?:J.M.Cortonetal.;Eur.J.Biochem.229,558(1995)
- 5-aminoimidazole-4-carboxamideribosidemimicstheeffectsofinsulinontheexpressionofthe2keygluconeogenicgenesPEPCKandglucose-6-phosphatase:P.A,Lochheadetal.;Diabetes49,896(2000)
- TheeffectsofAICARonadipocytedifferentiationof3T3-L1cells:S.A.Habinowskietal.;Biochem.Biophys.Res.Commun.286,852(2001)
- 5-Aminoimidazole-4-carboxamideribosideinducesapoptosisinJurkatcells,buttheAMP-activatedproteinkinaseisnotinvolved:J.M.Lopezetal.;Biochem.J.370,1027(2003)
- Kinase-independenttranscriptionalco-activationofperoxisomeproliferator-activatedreceptoralphabyAMP-activatedproteinkinase:M.Bronneretal.;Biochem.J.384,295(2004)
- AMP-activatedproteinkinaseactivatorscaninhibitthegrowthofprostatecancercellsbymultiplemechanisms:X.Xiangetal.;Biochem.Biophys.Res.Commun.321,161(2004)
- 5-Aminoimidazole-4-carboxamideribosidesuppresseslipopolysaccharide-inducedTNF-alphaproductionthroughinhibitionofphosphatidylinositol3-kinase/AktactivationinRAW264.7murinemacrophages:B.S.Jhunetal.;Biochem.Biophys.Res.Commun.318,372(2004)
- TheCREBcoactivatorTORC2isakeyregulatoroffastingglucosemetabolism:S.H.Kooetal.;Nature437,1109(2005)
- 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosideinhibitsproinflammatoryresponseinglialcells:apossIBLeroleofAMP-activatedproteinkinase:S.Giri,etal.;J.Neurosci.24,479(2004)
- 5-aminoimidazole-4-carboxamideribonucleoside(AICAR)inhibitsinsulin-stimulatedglucosetransportin3T3-L1adipocytes:I.P.Salt,etal.;Diabetes49,1649(2000)
- AICARinducesapoptosisindependentlyofAMPKandp53throughup-regulationoftheBH3-onlyproteinsBIMandNOXAinchroniclymphocyticleukemiacells:A.F.Santidrian,etal.;Blood116,3023(2010)
- AICARinhibitscancercellgrowthandtriggerscell-typedistincteffectsonOXPHOSbiogenesis,oxidativestressandAktactivation:C.Jose,etal.;Biochim.Biophys.Acta1807,707(2011)
- RoleofAMP-activatedproteinkinaseinautophagyandproteasomefunction:R.Viana,etal.;BBRC369,964(2008)
- Small-moleculetargetingofheatshockprotein90chaperonefunction:rationalidentificationofanewanticancerlead:M.Meli,etal.;J.Med.Chem.49,7721(2006)
- AMPKpromotesskeletalmuscleautophagythroughactivationofforkheadFoxO3aandinteractionwithUlk1:A.M.Sanchez,etal.;J.Cell.Biochem.113,695(2012)
- AMPKActivationbyZyflamend:Anovelpathwayregulatingmetabolismandgrowthinprostatecancer:A.F.MacDonald;Master"sThesis,UniversityofTennessee(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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