Adipogen/Agelasine D/AG-CN2-0492-M001/1 mg
商品编号：
AG-CN2-0492-M001
品牌：
Adipogen Inc
市场价：
¥3600.00
美元价：
2160.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (+)-AgelasineD |
| ProductType | Chemical |
| Properties | |
| Formula | C26H40N5 |
| MW | 422.6 |
| CAS | 92664-80-7 |
| Source/HostChemicals | IsolatedfromspongeAgelassp. |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Off-whitetocolorlesscrystals. |
| Solubility | SolubleinDMSO,ethanolormethanol. |
| Identity | Determinedby1H-NMRandMS. |
| InChiKey | SHVHRNDHUVXXIF-XGBZQHFCSA-O |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antifoulingcompound.
- Antimycobacterialandantibacterialagent.ExertsitsantibacterialeffectbyinhibitingenzymeBCG3185c,asUSPecteddioxygenasetherebydisruptingbacterialhomeostasis.
- AssociatedwithcontractiveresponsesofsmoothmusclesandinhibitionofNa+/K+ATPase.
- Cytotoxic/Antineoplasticagent.Foundtoexhibitinhibitoryactivityagainstseveralcancercelllines,includingthedrugresistantrenalcancercellline(ACHN).
- SuppressorofRANKL-inducedosteoclastogenesisviadown-regulationofc-Fos,NFATc1,NF-κBandERK.
- Antiprotozoalcompound.
ProductReferences
- Agelasine-A-B,-Cand-D,novelbicyclicditerpenoidswitha9-methyladeniniumunitpossessinginhibitoryeffectsonNa,K-ATPaseisolatedfromtheOkinawianseaspongeAgelassp:H.Nakamura,etal.;TetrahedronLett.25,2989(1984)
- (+)-agelasineD:improvedsynthesisandevaluationofantibacterialandcytotoxicactivities:A.Vik,etal.;J.Nat.Prod.69,381(2006)
- Synthesis,antimicrobialandantineoplasticactivitiesforagelasineandagelasimineanalogswithabeta-cyclocitralderivedsubstituent:A.Proszenyak,etal.;Arch.Pharm.340,625(2007)
- AntifoulingactivityofthespongemetaboliteagelasineDandsynthesisedanalogsonBalanusimprovisus:M.Sjoegren,etal.;Biofouling24,251(2008)
- ScreeningofAgelasineDandAnalogsforInhibitoryActivityagainstPathogenicProtozoa;IdentificationofHitsforVisceralLeishmaniasisandChagasDisease:A.Vik,etal.;Molecules14,279(2009)
- Fromanti-foulingtobiofilminhibition:NewcytotoxicsecondarymetabolitesfromtwoIndonesianAgelassponges:T.Hertiani,etal.;Bioorg.Med.Chem.18,1297(2010)
- SynthesisandBIOLOGicalactivitiesofmarineterpene-adeninehybridsandsyntheticanalogs:L.-L.Gundersen;Phytochem.Rev.12,467(2013)(Review)
- IdentificationofthetargetproteinofagelasineD,amarinespongediterpenealkaloid,asananti-dormantmycobacterialsubstance:M.Arai,etal.;Chembiochem.15,117(2014)
- AgelasineDsuppressesRANKL-inducedosteoclastogenesisviadown-regulationofc-Fos,NFATc1andNF-κB:M.R.Kang,etal.;Mar.Drugs12,5643(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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