Adipogen/Ageladine A . trifluoracetate/AG-CMA-1001-C200/200 µg
商品编号：
AG-CMA-1001-C200
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (4-(4,5-Dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]-pyridin-2-amine).TFA |
| ProductType | Chemical |
| Properties | |
| Formula | C10H7Br2N5.C2HF3O2 |
| MW | 357.0.114.0 |
| CAS | 950766-21-9|643020-13-7(freebase) |
| Source/HostChemicals | Synthetic.OriginallyisolatedfromAgelasnakamurai. |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Brownsolid. |
| Solubility | SolubleinDMSOormethanol. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyMarnasBiochemicals. |
| OtherProductData | Fluorescencespecifications: Excitation325-415nm;maximumat370nm Emission415-500nm;maximumat415nm Preparea1mMstocksolutioninMeOHorDMSO: Dissolve0.425mlmethanolintotheprovided0.2mgvialofAgelADIneA,mixgentlyuntilthecompoundiscompletelydissolved.Thesolutionshouldshowahomogenousyellowcolour.Usefreshpreparationsoraliquotandfreezeimmediately.AgeladineAislightsensitive,avoidlongerexpositiontodirectsunlightorotherintensivelightsources.Avoidfreeze/thawcyclesofsolutions. |
| InChiKey | QAKGJAQGTQLMFN-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +20°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Protectfromlightandmoisture. Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat+4°C. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Non-toxic,pH-sensitivefluorescentdye(blue-greenrange)forliveimagingofpHalterationinacidicorganelles,vesicles,cells,tissueandevensmallwholeanimalsoverseveraldayswithoutsideeffects[2,4,5,7-9].
- Strongerfluorescentintensityunderacidicconditionsandbarelydetectableinalkalinesolutions(widerangefrompH4topH8)[2].
- Highlycell/membranepermeable.Trappedwithinthecellsandacidicorganellesthroughhydrophobicinteractionswiththeinnersideofthemembranes[2].
- Barelymetabolizedandlong-termstable,thusslowphotobleaching[9].
- Angiogenesisinhibitor[1,3,6].
- InhibitorofmatrixmetalloproteinasesMMP-1,-2,-8,-9,-12,-13[1,3-6].
- TYK2,DYRK2,Dyrk1A,YSK4andRPS6KA1/2inhibitor[3,5,6].
ProductReferences
- AgeladineA:AnantigiogeneticmatrixmetalloproteinaseinhibitorfromthemarinespongeAgelasnakamurai:M.Fujita,etal.;JACS125,1570(2003)
- AgeladineA,apyrrole-imidazolealkaloidfrommarinesponges,isapHsensitivemembranepermeabledye:U.Bickmeyer,etal.;BBRC373,419(2008)
- SynthesisandanticanceractivitiesofageladineAandstructuralanalogs:Y.Ma,etal.;Bioorg.Med.Chem.Lett.20,83(2010)
- TrackingoffastmovingneuronalvesicleswithageladineA:U.Bickmeyer,etal.;BBRC402,489(2010)
- Aone-potsynthesisandBIOLOGicalactivityofageladineAandanalogues:S.R.Shengule,etal.;Med.Chem.54,2492(2011)
- Synthesisandmatrixmetalloproteinase-12inhibitoryactivityofageladineAanalogs:N.Ando&S.Terashima;Chem.Pharm.Bull.59,579(2011)
- ThealkaloidAgeladineA,originallyisolatedfrommarinesponges,usedforpH-sensitiveimagingoftransparentmarineanimals:U.Bickmeyer;Mar.Drugs10,223(2012)
- IncorporatednematocystsinAeolidiellastephanieae(Gastropoda,Opisthobranchia,Aeolidoidea)maturebyacidificationshownbythepHsensitivefluorescingalkaloidAgeladineA:D.Obermann,etal.;Toxicon60,1108(2012)
- ReporterdyesdemonstratefunctionalexpressionofmultidrugresistanceproteinsinthemarineflatwormMacrostomumlignano:Thesponge-deriveddyeageladineAisnotasubstrateofthesetransporters:K.Tietje,etal.;Mar.Drugs11,3951(2013)
- Marine-derivedangiogenesisinhibitorsforcancertherapy:Y.Q.Wang&Z.H.Miao;Mar.Drugs11,903(2013)
- ThephysiologicalresponseofthemarineplatyhelminthMacrostomumlignanotodifferentenvironmentaloxygenconcentrations:G.A.Rivera-Ingraham,etal.;J.Exp.Biol.216,2741(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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