Adipogen/Aftin-4/AG-MR-C0014-M005/5 mg
商品编号：
AG-MR-C0014-M005
品牌：
Adipogen Inc
市场价：
¥3600.00
美元价：
2160.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | N6-Methyl-(R)-roscovitine;Amyloid-βForty-TwoInducer4 |
| ProductType | Chemical |
| Properties | |
| Formula | C20H28N6O |
| MW | 368.5 |
| CAS | 866893-90-5 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOorethanol. |
| Reconstitution | Stocksolutionscanbemadeupto10mMinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | YPYWONAECUVKHY-MRXNPFEDSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Roscovitine-relatedpurinewithnoactivityonCDKs(usedascontrolforroscovitine).
- SelectivelyandpotentlyincreasesproductionofextracellularAβ42anddecreasesproductionofextracellularAβ38inculturedcells.ExtracellularAβ40levelsremainstable.Intracellularlevelsoftheseamyloidsappeartoremainstable.
- Alzheimer"sDisease(AD)acceleratorthatinteractswithVDAC1,prohibitinandmitofilin,possIBLyinterferingwithsubcellularcompartmentalizationandlipidraftsproperties,shiftingγ-secretaseactivitytowardAβ42generation.
- InducesareversiblemitochondrialphenotypereminiscentoftheoneobservedinADbrains.
- TooltodetectinhibitorsofAftin-inducedactions(potentialanti-ADcompounds).
- Bindspyridoxalkinase.
ProductReferences
- Roscovitinetargets:proteinkinasesandpyridoxalkinase:S.Bach,etal.;J.Biol.Chem.280,31208(2005)
- Crystalstructureofpyridoxalkinaseincomplexwithroscovitineandderivatives:L.Tang,etal.;J.Biol.Chem.280,31220(2005)
- Small-moleculeinducersofAβ-42peptideproductionshareacommonmechanismofaction:K.Bettayeb,etal.;FASEBJ.26,5115(2012)
- Aftinsincreaseamyloid-β42,loweramyloid-β38,anddonotalteramyloid-β40extracellularproductioninvitro:towardachemicalmodelofAlzheimer"sdisease?:A.Hochard,etal.;J.AlzheimersDis.35,107(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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