Adipogen/AEBSF . hydrochloride/AG-CR1-3610-M250/250 mg
商品编号：
AG-CR1-3610-M250
品牌：
Adipogen Inc
市场价：
¥2800.00
美元价：
1680.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 4-(2-Aminoethyl)benzenesulfonylfluoride;PefablocSC |
| ProductType | Chemical |
| Properties | |
| Formula | C8H10FNO2S.HCl |
| MW | 203.2.36.5 |
| CAS | 30827-99-7 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitesolid. |
| Solubility | Solubleinwateror100%ethanol. |
| InChiKey | WRDABNWSWOHGMS-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Watersoluble,irreversIBLeserineprotease(chymotrypsin,kallikrein,plasmin,thrombinandtrypsin)inhibitor.Stable,non-toxicalternativetoPMSF.
- Potent,selectiveinhibitorofSite-1-protease(S1P).
- UsedtocharacterizethedownstreamresultofSREBPinhibitionanditsinfluenceoncholesterolregulationbyselectivelyinhibitingS1P.
- NAD(P)Hoxidaseinhibitor.
- InhibitsactivationofTGFβandactivatesJNKandp38MAPkinases.
- β-Secretaseinhibitor.Showntoinhibitβ-amyloidpeptideproductionandenhanceAPP(amyloidprecursorprotein)secretioninseveralcelllinesatmillimolarconcentrations.
ProductReferences
- Irreversibleenzymeinhibitors.180.IrreversibleinhibitorsoftheClacomponentofcomplementderivedfromm-(phenoxypropoxy)benzamidineandphenoxyacetamide:B.R.Baker&M.Cory;J.Med.Chem.14,119(1971)
- Syntheticlowmolecularweightinhibitorsofserumkallikrein:F.Markwardt,etal.;Biochem.Pharmacol.23,2247(1974)
- Inhibitionofamyloidbeta-proteinproductioninneuralcellsbytheserineproteaseinhibitorAEBSF:M.Citron,etal.;Neuron17,171(1996)
- InhibitionofNADPHoxidaseactivationby4-(2-aminoethyl)-benzenesulfonylfluorideandrelatedcompounds:V.Diatchuk,etal.;J.Biol.Chem.272,13292(1997)
- 4-(2-Aminoethyl)benzenesulfonylfluorideattenuatestumor-necrosis-factor-alpha-inducedblood-brainbarrieropening:P.Megyeri,etal.;Eur.J.Pharmacol.374,207(1999)
- Irreversibleinhibitorsofserine,cysteine,andthreonineproteases:J.C.Powers,etal.;Chem.Rev.102,4639(2002)
- Aserineproteaseinhibitorpreventsendoplasmicreticulumstress-inducedcleavagebutnottransportofthemembrane-boundtranscriptionfactorATF6:T.Okada,etal.;J.Biol.Chem.278,31024(2003)
- ProteolyticactivationoflatentTGF-betaprecedescaspase-3activationandenhancesapoptoticdeathoflungepithelialcells:V.T.Solovyan&J.Keski-Oja;J.CellPhysiol.207,445(2006)
- Serineproteaseinhibitorattenuatesovalbumininducedinflammationinmousemodelofallergicairwaydisease:S.Saw,etal.;PLoSOne7,e41107(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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