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Adipogen/AdipoRon . hydrochloride (water soluble)/AG-CR1-0156-M010/10 mg
Adipogen/AdipoRon . hydrochloride (water soluble)/AG-CR1-0156-M010/10 mg
商品编号：
AG-CR1-0156-M010
品牌：
Adipogen Inc
市场价：
¥1400.00
美元价：
840.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide |
| Product Type | Chemical |
| Properties | |
| Formula | C27H28N2O3 . HCl . H2O |
| MW | 428.5 . 36.5 . 18.0 |
| CAS | 924416-43-3 (free base) |
| Purity Chemicals | ≥98% (HPLC, NMR) |
| Appearance | White solid. |
| Solubility | Highly soluble in DMSO (~50mg/ml). Soluble in 100% ethanol or methanol. Slightly soluble in water (1mg/ml). |
| Identity | Determined by 1H-NMR. |
| InChi Key | TZVJQEGKRLDTHQ-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low μm concentration [1, 2].
- Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells [1].
- Activates peroxisome proliferator-activated receptor γ coactivator 1-α (PGC1α) which boosts mitochondrial proliferation and energy metabolism [1].
- Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms [1].
- Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet [1].
- Reduces expression levels of genes encoding inflammatory cytokines such as TNF-α, IL-6 and CCL-2 in WAT of WT mice but not db/db mice [1].
Product References
- A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity: M. Okada-Iwabu, et al.; Nature 503, 493 (2013)
- Cell Biology. Ronning after the adiponectin receptors: W.L. Holland & P.E. Scherer; Science 342, 1460 (2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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