Adipogen/ACY-775/AG-CR1-3903-M001/1 mg
商品编号：
AG-CR1-3903-M001
品牌：
Adipogen Inc
市场价：
¥2800.00
美元价：
1680.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide |
| ProductType | Chemical |
| Properties | |
| Formula | C17H19FN4O2 |
| MW | 330.4 |
| CAS | 1375466-18-4 |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Offwhitesolid. |
| Solubility | SolubleinDMSO,methanolorethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | IYBURCQQEUNLDL-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,potentandselectiveclassIIbHDAC6inhibitor(IC50=7.5nM).DisplayshighselectivityoverHDAC1-9(IC50=1-10µM).
- ShowsimprovedbrainbioavailabilitycomparedtotubastatinA(Prod.No.AG-CR1-3900).
- Induceshyperacetylationofα-tubulininbrainwithoutconcurrentlyalteringtheacetylationofhistones.
- Showsantidepressantactivity.
- HDAC6deacetylatestubulin,HSP90andthecorehistones(H2A,H2B,H3,H4).Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.HDAC6playsanimportantroleinmicrotubule-dependentcellmotility,transcriptionalregulation,degradationofmisfoldedproteinsandcellcycleandisinvolvedinautophagy,inflammation,cancerandneurodegeneration.
ProductReferences
- Histonedeacetylase(HDAC)inhibitorsassingleagentsinducemultiplemyelomacelldeathprincipallythroughtheinhibitionofclassIHDAC:S.Mithraprabhu,etal.;Br.J.Haematol.162,559(2013)
- PrognosticandtherapeuticrelevanceofFLIPandprocaspase-8overexpressioninnon-smallcelllungcancer:J.S.Riley,etal.;CellDeathDis.4,e951(2013)
- RPL24:apotentialtherapeutictargetwhosedepletionoracetylationinhibitspolysomeassemblyandcancercellgrowth:K.A.Wilson-Edell,etal.;Oncotarget5,5165(2014)
- Antidepressant-likepropertiesofnovelHDAC6-selectiveinhibitorswithimprovedbrainbioavailability:J.Jochems,etal.;Neuropsychopharmacol.39,389(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
