脂肪原/放线菌素D/BVT-0089-M005/5 mg
商品编号：
BVT-0089-M005
品牌：
Adipogen Inc
市场价：
¥1200.00
美元价：
720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ActinomycinIV;ActinomycinC1;Dactinomycin |
| ProductType | Chemical |
| Properties | |
| Formula | C62H86N12O16 |
| MW | 1255.4 |
| MerckIndex | 14:2800 |
| CAS | 50-76-0 |
| RTECS | AU1575000 |
| Source/HostChemicals | IsolatedfromStreptomycesparvulus. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Redshinycrystals. |
| Solubility | SolubleinDMSO,100%ethanolormethanol. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| OtherProductData | Sensitivetostrongacidsandbases. |
| InChiKey | ZOWMRHVAQGTFTG-IZRKADTCSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat+4°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic.
- Antitumorcompound[2].
- Cytotoxic[2].
- Apoptosisinducer[1,2,6,7].
- RNAsynthesisinhibitor[4].
- DNAintercalatingagent[3,5].
- Mcl-1expressioninhibitor[8]
- p53pathwayactivator[9].
ProductReferences
- ApoptosisinducedbyActinomycinD,CamptothecinorAphidicolincanoccurinallphasesofthecellcycle:J.M.Glynn,etal.;Biochem.Soc.Trans.20,84S(1992)
- ActinomycinDinducesapoptosisandinhibitsgrowthofpancreaticcancercells:J.Kleeff,etal.;Int.J.Cancer86,399(2000)
- InfluenceofDNAbasesequenceonthebindingenergeticsofactinomycinD:S.A.Bailey,etal.;Biochemistry32,5881(1993)
- EffectofactinomycinonRNAsynthesisandantibodyformationintheanamnesticresponseinvitro:J.D.Smiley,etal.;J.Exp.Med.119,881(1964)
- NMRSolutionStructureofaDNA-ActinomycinDComplexContainingaNon-Hydrogen-BondingPairintheBindingSite:S.L.Cravens,etal.;J.Am.Chem.Soc. 132,17588 (2010)
- ActinomycinDupregulatesproapoptoticproteinPumaanddownregulatesBcl-2mRNAinnormalperipheralbloodlymphocytes:I.Kalousek,etal.;AnticancerDrugs18,763(2007)
- ActinomycinDenhancesTRAIL-inducedcaspase-dependentand-independentapoptosisinSH-SY5Yneuroblastomacells:M.J.Wang,etal.;Neurosci.Res.59,40(2007)
- ActinomycinDsynergisticallyenhancestheefficacyoftheBH3mimeticABT-737bydownregulatingMcl-1expression:K.E.Olberding,etal.;CancerBiol.Ther.10,930(2010)
- Specificactivationofthep53pathwaybylowdoseactinomycinD:M.L.Choong,etal.;CellCycle8,2810(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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