Adipogen/Ac-Arg-Leu-Arg-AMC/AG-CP3-0013-M005/5 mg
商品编号：
AG-CP3-0013-M005
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Ac-RLR-AMC . TFA; Proteasome Substrate |
| Product Type | Chemical |
| Properties | |
| Formula | C30H46N10O6 . C2HF3O2 |
| MW | 642.8 . 114.0 |
| Sequence | Acetyl-Arg-Leu-Arg-7-amido-4-methylcoumarin |
| CAS | 929903-87-7 (free base) |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Solid lyophilized powder. |
| Solubility | Soluble in 5% acetic acid. |
| Other Product Data | Use: Add from DMSO stock directly to in vitro or in vivo assay at desired concentration. Typical concentrations range from 10-100 μM. Activity with purified proteasome: Km=78μM. |
| InChi Key | CEEMPRHZPRGAAK-RGRVRPFLSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Protect from light. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome.
- It is cleaved exclusively at the amide R-AMC bond to release fluorescent product.
- Shows low Km and high specific activity. Excitation: 380nm. Emission: 460nm.
- This substrate is useful for inhibitor screening and kinetic analysis.
Product References
- Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates: K.J. Rodgers & R.T. Dean; Int. J. Biochem. Cell Biol. 35, 716 (2003)
- Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates: A.F. Kisselev & A.L. Goldberg; Methods Enzymol. 398, 364 (2005)
- Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate: A.F. Kisselev, et al.; J. Biol. Chem. 281, 8582 (2006)
- 5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor: T.L. Chang, et al.; Planta Med. 76, 987 (2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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