Adipogen/ABT-737/SYN-1001-M050/50 mg
商品编号：
SYN-1001-M050
品牌：
Adipogen Inc
市场价：
¥11440.00
美元价：
6864.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ABT737 |
| ProductType | Chemical |
| Properties | |
| Formula | C42H45ClN6O5S2 |
| MW | 813.4 |
| CAS | 852808-04-9 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO.Slightlysoluble(<1mg l)="" in="" ethanol.=""> |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:Bcl-2|KinaseGroup:PPI|Substrate:N/A ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | HPLNQCPCUACXLM-PGUFJCEWSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
ABT-737isasmall-moleculeinhibitoroftheanti-apoptoticproteinsBcl-2,Bcl-X(L)andBcl-w,withanaffinitytwotothreeordersofmagnitudemorepotentthanpreviouslyreportedcompounds.MechaNISTicstudiesrevealthatABT-737doesnotdirectlyinitiatetheapoptoticprocess,butenhancestheeffectsofdeathsignals,displayingsynergisticcytotoxicitywithchemotherapeuticsandrADIation.ABT-737exhibitssingle-agent-mechanism-basedkillingofcellsfromlymphomaandsmall-celllungcarcinomalines,aswellasprimarypatient-derivedcells,andinanimalmodels,ABT-737improvessurvival,causesregressionofestablishedtumors,andproducescuresinahighpercentageofthemice.ABT-737bindstoBcl-2,Bcl-xLandBcl-wwithveryhighaffinities(Ki<1 nm)="" and="" also="" shows="" a="" very="" high="" specificity="" over="" mcl-1="" and="">
ProductReferences
- AninhibitorofBcl-2familyproteinsinducesregressionofsolidtumours:T.Oltersdorf,etal.;Nature435,677(2005)
- SynthesisandBIOLOGicalactivitiesofnewdi-andtrimericquinolinederivatives:S.Broch,etal.;Bioorg.Med.Chem.18,7132(2010)
- DiscoveryofpotentandselectivebenzothiazolehydrazoneinhibitorsofBcl-XL:B.E.Sleebs,etal.;J.Med.Chem.56,5514(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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