Adipogen/A-674563 (free base)/AG-CR1-3680-M010/10 mg
商品编号：
AG-CR1-3680-M010
品牌：
Adipogen Inc
市场价：
¥4200.00
美元价：
2520.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | αS-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-benzeneethanamine |
| ProductType | Chemical |
| Properties | |
| Formula | C22H22N4O |
| MW | 358.4 |
| CAS | 552325-73-2 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMF(20mg/ml),DMSO(10mg/ml)orethanol(10mg/ml). |
| InChiKey | BPNUQXPIQBZCMR-IBGZPJMESA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- A-674563isapotent,ATP-competitive,reversIBLeandorallyavailableAkt1inhibitorwithanIC50of11nM.BindstotheATPsiteoftheAKTkinasedomain,inhibitingAKT-catalyzedphosphorylationactivity.
- AlsoinhibitsPKAandCDK2withIC50valuesof16nMand46nM,respectively.
- 10-to>1,800-foldselectiveforAkt1versusadditionalkinasesintheCMGC,CAMKandTKfamilies.
- Anticancercompound.ReducesphosphorylationofAktdownstreamtargetsincellsandslowsproliferationoftumorcellsinvitrowithanEC50valueof0.4µM.
- Showntodecreasetumorgrowthinmousetumorxenograftmodels.
- Decreasedsphingosinekinase1(SphK1)activityinAMLcellstodepletepro-survivalsphingosine-1-phosphate(S1P)andboostpro-apoptoticceramideproduction.
ProductReferences
- PotentandselectiveinhibitorsofAktkinasesslowtheprogressoftumorsinvivo:Y.Luo,etal.;Mol.CancerTher.4,977(2005)
- CharacterizationofanAktkinaseinhibitorwithpotentpharmacodynamicandantitumoractivity:N.Rhodes,etal.;CancerRes.68,2366(2008)
- SofttissuesarcomacellsarehighlysensitivetoAKTblockade:aroleforp53-independentup-regulationofGADD45alpha:Q.S.Zhu,etal.;CancerRes.68,2895(2008)
- EnhancedsensitivitytosorafenibbyinhibitionofAkt1expressioninhumanrenalcellcarcinomaACHNcellsbothinvitroandinvivo:H.Tei,etal.;Hum.Cell.28,114(2015)
- UniquerolesofAkt1andAkt2inIGF-IRmediatedlungtumOrigenesis:S.E.Franks,etal.;Oncotarget7,3297(2016)
- DualinhibitionofAKT/FLT3-ITDbyA674563overcomesFLT3ligand-induceddrugresistanceinFLT3-ITDpositiveAML:A.Wang,etal.;Oncotarget7,29131(2016)
- ConcurrenttargetingAktandsphingosinekinase1byA-674563inacutemyeloidleukemiacells:L.Xu,etal.;BBRC472,662(2016)
- Pre-clinicalassessmentofA-674563asananti-melanomaagent:Y.Zou,etal.;BBRC477,1(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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