脂肪原/A-443654/AG-CR1-3663-M001/1毫克
商品编号：
AG-CR1-3663-M001
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (S)-1-(1H-Indol-3-yl)-3-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)propan-2-amine |
| ProductType | Chemical |
| Properties | |
| Formula | C24H23N5O |
| MW | 397.5 |
| CAS | 552325-16-3 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(15mg/ml),ethanol(10mg/ml)orDMF(20mg/ml). |
| Identity | Determinedby1H-NMR. |
| InChiKey | YWTBGJGMTBHQTM-IBGZPJMESA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Keepunderinertgas. Protectfrommoistureandoxygen. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentandselectiveAktinhibitor(Ki=160pmol/LforallthreeisoformsPKBα,PKBβandPKBγ).
- DYRK1Ainhibitor(IC50=10nM).Inhibitsotherkinases,includingPRK2,MSK1andDYRK3atlownMrangeaswell.
- Interfereswithmitoticprogressionbyregulatingauroraakinaseexpressionandbipolarspindleformation.ItinducesG2/Maccumulation,defectsincentrosomeseparationandformationofeithermonopolararraysordisorganizedspindles.
- Anticanceragent.Apoptosisinducerandchemosensitizingagent.SlowstheprogressionandgrowthofAkt-dependenttumors.
- InducesrapidAktSer473phosphorylationindependentofmTORC1inhibitioninhumancancercelllines.
- ActivatesmTORC2andreverseslong-termmemorydeficits.
ProductReferences
- PotentandselectiveinhibitorsofAktkinasesslowtheprogressoftumorsinvivo:L.Luo,etal.;Mol.CancerTher.4,977(2005)
- AktinhibitorA-443654inducesrapidAktSer-473phosphorylationindependentofmTORC1inhibition:E.K.Han,etal.;Oncogene26,5655(2007)
- AroleforAktinepidermalgrowthfactor-stimulatedcellcycleprogressioninculturedhepatocytes:generationofahyperproliferativewindowafteradenoviralexpressionofconstitutivelyactiveAkt:Y.Luo,etal.;J.Pharmacol.Exp.Ther.321,884(2007)
- Theselectivityofproteinkinaseinhibitors:afurtherupdate:J.Bain,etal.;Biochem.J.408,297(2007)
- ProapoptoticactivityandchemosensitizingeffectofthenovelAktinhibitor(2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine(A443654)inT-cellacutelymphoblasticleukemia:F.Fala,etal.;Mol.Pharmacol.74,884(2008)
- Aktinhibitora-443654interfereswithmitoticprogressionbyregulatingauroraakinaseexpression:X.Liu,etal.;Neoplasia10,828(2008)
- InhibitionofAktinhibitsgrowthofglioblastomaandglioblastomastem-likecells:G.L.Gallia,etal.;Mol.CancerTher.8,386(2009)
- Aktinhibitorsinduceapoptosisinchroniclymphocyticleukemiacells:M.deFrias,etal.;Haematologica94,1698(2009)
- AnallostericAktinhibitoreffectivelyblocksAktsignalingandtumorgrowthwithonlytransienteffectsonglucoseandinsulinlevelsinvivo:C.Cherrin,etal.;CancerBiol.Ther.9,493(2010)
- RecentAdvancesintheDesign,Synthesis,andBIOLOGicalEvaluationofSelectiveDYRK1AInhibitors:ANewAvenueforaDiseaseModifyingTreatmentofAlzheimer"s:B.Smith,etal.;ACSChem.Neurosci.3,857(2012)
- TORC2:anoveltargetfortreatingage-associatedmemoryimpairment:J.L.Johnson,etal.;Sci.Rep.5,15193(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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