Adipogen/7BIO/AG-MR-C0020-M050/50 mg
商品编号：
AG-MR-C0020-M050
品牌：
Adipogen Inc
市场价：
¥10400.00
美元价：
6240.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 7-Bromoindirubin-3"-oxime |
| ProductType | Chemical |
| Properties | |
| Formula | C16H10BrN3O2 |
| MW | 356.2 |
| CAS | 916440-85-2 |
| PurityChemicals | ≥99%(NMR) |
| Appearance | Darkredsolid. |
| Solubility | SolubleinDMSOorethanol. |
| Reconstitution | Stocksolutionscanbemadeupto10mMinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | DDLZLOKCJHBUHD-WAVHTBQISA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anticancercompound.
- Caspase-independent,non-apoptoticcelldeathinducer.
- ATP-competitiveFlt3inhibitor.
- Necrosisinducer.
- AuroraBandCkinaseinhibitor.
- DYRK1AandDYRK2(Dual-specificitytyrosinephosphorylation-regulatedkinase)inhibitor.
- Inflammasomeactivator.
ProductReferences
- Indirubin,theredshadeofindigo:L.Meijer,etal.(Editors):In«LifeinProgress»,StationBIOLOGique,Roscoff,297pp.(2006)
- 3"-substituted7-Halogenoindirubins,anewclassofcelldeathinducingagents:Y.Ferandin,etal.;J.Med.Chem.49,4638(2006)
- 7-Bromoindirubin-3"-oximeinducescaspase-independentcelldeath:J.Ribas,etal.;Oncogene25,6304(2008)
- Inverseinsilicoscreeningforidentificationofkinaseinhibitortargets:S.Zahler,etal.;Chem.Biol.14,1207(2007)
- AnintegratedcomputationalapproachtothephenomenonofpotentandselectiveinhibitionofaurorakinasesBandCbyaseriesof7-substitutedindirubins:V.Myrianthopoulos,etal.;J.Med.Chem.50,4027(2007)
- 7-Bromoindirubin-3"-oximeuncoversaserineprotease-mediatedparADIgmofnecroticcelldeath:J.Ribas,etal.;Biochem.Pharmacol.76,39(2008)
- Cuttingedge:NecrosisactivatestheNLRP3inflammasome:H.Li,etal.;J.Immunol.183,1528(2009)
- Anticancereffectsandantimetastaticmechanismsofnovelindirubinderivatives:C.A.Kressirer;Diss.Ludwig-Maximilians-UniversitaetMunchen,(2010)
- Inductionofdiscreteapoptoticpathwaysbybromo-substitutedindirubinderivativesininvasivebreastcancercells:K.A.Nicolaou,etal.;BBRC425,76(2012)
- FromTyrianpurpletokinasemodulators:naturallyhalogenatedindirubinsandsyntheticanalogues:K.Vougogiannopoulou&AL.Skaltsounis;PlantaMed.78,1518(2012)
- Anovel7-bromoindirubinwithpotentanticanceractivitysuppressessurvivalofhumanmelanomacellsassociatedwithinhibitionofSTAT3andAktsignaling:L.Liu,etal.;CancerBiol.Ther.13,1255(2012)
- NovelinversebindingmodeofindirubinderivativesyieldsimprovedselectivityforDYRKkinases:V.Myrianthopoulos,etal.;ACSMed.Chem.Lett.4,22(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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