Adipogen/6BIO/AG-CR1-0056-M025/25 mg
商品编号：
AG-CR1-0056-M025
品牌：
Adipogen Inc
市场价：
¥5200.00
美元价：
3120.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (2’Z,3’E)-6-Bromoindirubin-3’-oxime |
| ProductType | Chemical |
| Properties | |
| Formula | C16H10BrN3O2 |
| MW | 356.2 |
| CAS | 667463-62-9 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Darkredsolid. |
| Solubility | SolubleinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | DDLZLOKCJHBUHD-WAVHTBQISA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Phosphoinositide-dependentkinase1(PDK1)inhibitor.
- Potent,reversIBLeandATP-competitiveglycogensynthasekinase-3α/β(GSK-3α/β)inhibitor.
- JAK/STAT3signalinginhibitor.
- Apoptosisinducer.
- Potentantiproliferativeagentinmalignantlymphoidcell.
- Antimetastaticagent.
- PotentchemosensitizingagentfightingTRAILresistantcancercells.
ProductReferences
- GSK-3-selectiveinhibitorsderivedfromTyrianpurpleindirubins:L.Meijer,etal.;Chem.Biol.10,1255(2003)
- Structuralbasisforthesynthesisofindirubinsaspotentandselectiveinhibitorsofglycogensynthasekinase-3andcyclin-dependentkinases:P.Polychronopoulos,etal.;J.Med.Chem.47,935(2004)
- TheGSK-3inhibitorBIOpromotesproliferationinmammaliancardiomyocytes:A.S.Tseng,etal.;Chem.Biol.13,957(2006)
- 7-Bromoindirubin-3"-oximeinducescaspase-independentcelldeath:J.Ribas,etal.;Oncogene25,6304(2006)
- Inverseinsilicoscreeningforidentificationofkinaseinhibitortargets:S.Zahler,etal.;Chem.Biol.14,1207(2007)
- AnintegratedcomputationalapproachtothephenomenonofpotentandselectiveinhibitionofaurorakinasesBandCbyaseriesof7-substitutedindirubins:V.Myrianthopoulos,etal.;J.Med.Chem.50,4027(2007)
- Indirubinderivativesinhibitmalignantlymphoidcellproliferation:A.Chebel,etal.;Leuk.Lymphoma50,2049(2009)
- 6-Bromoindirubin-3"-OximeInhibitsJAK/STAT3SignalingandInducesApoptosisofHumanMelanomaCells:L.Liu,etal.;CancerRes.71,3972(2011)
- Indirubinderivative6BIOsuppressesmetastasis:S.Braig,etal.;CancerRes.73,6004(2013)
- Thepleiotropicprofileoftheindirubinderivative6BIOovercomesTRAILresistanceincancer:S.Braig,etal.;Biochem.Pharmacol.91,157(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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