Adipogen/6BIO/AG-MR-C0019-M010/10 mg
商品编号：
AG-MR-C0019-M010
品牌：
Adipogen Inc
市场价：
¥2400.00
美元价：
1440.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | BIO;6-Bromoindirubin-3"-oxime |
| ProductType | Chemical |
| Properties | |
| Formula | C16H10BrN3O2 |
| MW | 356.2 |
| CAS | 667463-62-9 |
| PurityChemicals | ≥99%(NMR) |
| Appearance | Darkredsolid. |
| Solubility | SolubleinDMSOorethanol. |
| Reconstitution | Stocksolutionscanbemadeupto10mMinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | DDLZLOKCJHBUHD-WAVHTBQISA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,reversIBLeandATP-competitiveglycogensynthasekinase-3α/β(GSK-3α/β)inhibitor.
- JAK/STAT3signalinginhibitor.
- Phosphoinositide-dependentkinase1(PDK1)inhibitor.
- Anticancercompound.
- Potentantiproliferativeagent.Suppressesmetastasis.
- Apoptosisinducer.
- Sustainspluripotencyandself-renewalofhumanandmouseembryonicstemcells(ESCs)byactivationoftheWntsignalingpathway.
- Anti-leishmanial(IC50=0.150μM).
- Proto-oncogenetyrosine-proteinkinasereceptorRETinhibitor(IC50=0.51μM).
- InhibitsHIV-1transcriptionandprotectsagainstTatinducedneurotoxicity.
ProductReferences
- GSK-3-selectiveinhibitorsderivedfromTyrianpurpleindirubins:L.Meijer,etal.;Chem.Biol.10,1255(2003)
- Structuralbasisforthesynthesisofindirubinsaspotentandselectiveinhibitorsofglycogensynthasekinase-3andcyclin-dependentkinases:P.Polychronopoulos,etal.;J.Med.Chem.47,935(2004)
- MaintenanceofpluripotencyinhumanandmouseembryonicstemcellsthroughactivationofWntsignalingbyapharmacologicalGSK-3-specificinhibitor:N.Sato,etal.;Nat.Med.10,55(2004)
- TheGSK-3inhibitorBIOpromotesproliferationinmammaliancardiomyocytes:A.S.Tseng,etal.;Chem.Biol.13,957(2006)
- 7-Bromoindirubin-3"-oximeinducescaspase-independentcelldeath:J.Ribas,etal.;Oncogene25,6304(2006)
- Indirubin,theredshadeofindigo:L.Meijer,etal.(Editors):In«LifeinProgress»,StationBIOLOGique,Roscoff,297pp.(2006)
- Indirubinderivativesinhibitmalignantlymphoidcellproliferation:A.Chebel,etal.;Leuk.Lymphoma50,2049(2009)
- 6-Br-5methylindirubin-3"oxime(5-Me-6-BIO)targetingtheleishmanialglycogensynthasekinase-3(GSK-3)shortformaffectscell-cycleprogressionandinducesapoptosis-likedeath:ExploitationofGSK-3fortreatingleishmaniasis:E.Xingi,etal.;Int.J.Parasit.39,1289(2009)
- Anticancereffectsandantimetastaticmechanismsofnovelindirubinderivatives:C.A.Kressirer;Diss.Ludwig-Maximilians-UniversitaetMunchen,(2010)
- 6-Bromoindirubin-3"-OximeInhibitsJAK/STAT3SignalingandInducesApoptosisofHumanMelanomaCells:L.Liu,etal.;CancerRes.71,3972(2011)
- InhibitionofTat-mediatedHIV-1replicationandneurotoxicitybynovelGSK3-betainhibitors:K.Kehn-Hall,etal.;Virology415,56(2011)
- Inductionofdiscreteapoptoticpathwaysbybromo-substitutedindirubinderivativesininvasivebreastcancercells:K.A.Nicolaou,etal.;BBRC425,76(2012)
- FromTyrianpurpletokinasemodulators:naturallyhalogenatedindirubinsandsyntheticanalogues:K.Vougogiannopoulou&A.L.Skaltsounis;PlantaMed.78,1518(2012)
- Pleiotrophinsuppressionofreceptorproteintyrosinephosphatase-β/ζmaintainstheself-renewalcompetenceoffetalhumanoligodendrocyteProgenitorcells:C.R.McClain,etal.;J.Neurosci.32,15066(2012)
- NovelinversebindingmodeofindirubinderivativesyieldsimprovedselectivityforDYRKkinases:V.Myrianthopoulos,etal.;ACSMed.Chem.Lett4,22(2013)
- IndirubinDerivative6BIOSuppressesMetastasis:S.Braig,etal.;CancerRes.73,6004(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
