Adipogen/6-ECDCA/AG-CR1-3560-M005/5 mg
商品编号：
AG-CR1-3560-M005
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 6α-Ethyl-chenodeoxycholicacid;6-α-ECDC;Obeticholicacid;INT-747;OCA |
| ProductType | Chemical |
| Properties | |
| Formula | C26H44O4 |
| MW | 420.6 |
| CAS | 459789-99-2 |
| PurityChemicals | ≥95%(NMR) |
| Appearance | Whitesolid. |
| Solubility | Solubleinethanol,methanol,orDMSO.Slightlysolubleinwater,dichloromethaneandacetone. |
| Identity | Identitydeterminedby1H-NMR. |
| InChiKey | ZXERDUOLZKYMJM-AMGBFIHRSA-N |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentandselectiveFXRagoNIST(EC50=99nM)[1].
- InducesSHPinHSCstosuppressTIMP-1expression[2].
- Apoptosisinducer[2].
- Protectsagainstliverfibrosisdevelopmentinrat invivo [2].
- Displaysanticholereticactivityinratinvivo[3].
- PromotespreADIpocytedifferentiation[4].
- RegulatesAdipogenesisandinsulinsignaling invivo[4].
- Inhibitsvascularsmoothmusclecellinflammationandmigration[5].
ProductReferences
- 6r-Ethyl-chenodeoxycholicacid(6-ECDCA),apotentandselectiveFXRagonistendowedwithanticholestaticactivity:R.Pellicciari,etal.;J.Med.Chem.45,3569(2002)
- AfarnesoidXreceptor-smallheterodimerpartnerregulatorycascademodulatestissuemetalloproteinaseinhibitor-1andmatrixmetalloproteaseexpressioninhepaticstellatecellsandpromotesresolutionofliverfibrosis:S.Fiorucci,etal.;J.Pharmacol.Exp.Ther. 314,584(2005)
- Protectiveeffectsof6-ethylchenodeoxycholicacid,afarnesoidXreceptorligand,inestrogen-inducedcholestasis:S.Fiorucci,etal.;J.Pharmacol.Exp.Ther.313,604(2005)
- ThefarnesoidXreceptorpromotesadipocytedifferentiationandregulatesadiposecellfunctioninvivo:G.Rizzo,etal.;Mol.Pharmacol.70,1164(2006)
- FarnesoidXreceptorligandsinhibitvascularsmoothmusclecellinflammationandmigration:Y.T.Li,etal.;Arterioscler.Thromb.Vasc.Biol.27,2606(2007)
- ComputationaldiscoveryandexperimentalverificationoffarnesoidXreceptoragonistauraptenetoprotectagainstcholestaticliverinjury:X.Gao,etal.;Biochem.Pharmacol.aheadofprint(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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