Adipogen/6-Aminophenanthridine/AG-MR-C0029-M001/1 mg
商品编号：
AG-MR-C0029-M001
品牌：
Adipogen Inc
市场价：
¥800.00
美元价：
480.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 6AP |
| Product Type | Chemical |
| Properties | |
| Formula | C13H10N2 |
| MW | 194.2 |
| CAS | 832-68-8 |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Beige solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Reconstitution | Stock solutions can be made up to 10mM in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | FVCXJXKLDUJOFA-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After reconstitution, prepare aliquots and store at -20°C. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Antiprion agent.
- Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome.
- Inhibitor of protein aggregation.
Product References
- An expeditious synthesis of 6-aminophenanthridines: F. Gug, et al.; THL 46, 3725 (2005)
- Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs: D. Tribouillard-Tanvier, et al.; PLoS One 3, e2174 (2008)
- Tools for the study of ribosome-borne protein folding activity: C. Voisset, et al.; Biotechnol. J. 3, 1033 (2008)
- Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding: S.D. Reis, et al.; Biochimie 93, 1047 (2011)
- Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy: N. Barbezier, et al.; EMBO Mol. Med. 3, 35 (2011)
- The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition: Y. Pang, et al.; J. Biol. Chem. 288, 19081 (2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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