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Adipogen/5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione/CDX-P0110-M005/5 mg
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Adipogen/5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione/CDX-P0110-M005/5 mg
商品编号：
CDX-P0110-M005
品牌：
Adipogen Inc
市场价：
¥1760.00
美元价：
1056.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione; SMI-16a |
| Product Type | Chemical |
| Properties | |
| Formula | C13H13NO3S |
| MW | 263.3 |
| CAS | 587852-28-6 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Yellow powder. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | GBWOSXZUTXXXQF-FLIBITNWSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 µM). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20| 50 mg/kg via daily i.p.).
Product References
(1) Z. Xia, et al.; J. Med. Chem. 52, 74 (2009) | (2) Y.-W. Lin, et al.; Blood 115, 824 (2010) | (3) Z. Beharry, et al.; PNAS 108, 528 (2011) | (4) B. Cen, et al.; Cancer Res. 73, 3402 (2013) | (5) B. Cen, et al.; Mol. Cell. Biol. 34, 2517 (2014) | (6) M. Hiasa, et al.; Leukemia 29, 207 (2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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