Adipogen/5-Fluorocytosine/CDX-F0077-G005/5 g
商品编号：
CDX-F0077-G005
品牌：
Adipogen Inc
市场价：
¥11300.00
美元价：
6780.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 4-Amino-5-fluoro-2(1H)-pyrimidinone; Flucytosine; NSC 103805; Ancotil; 5-FC; Ancobon; Ro 2-9915 |
| Product Type | Chemical |
| Properties | |
| Formula | C4H4FN3O |
| MW | 129.09 |
| CAS | 2022-85-7 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥99% (TLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water. |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | XRECTZIEBJDKEO-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Fluorinated pyrimidine analog. Antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil (a widely used cytotoxic drug) and further metabolized to fluorinated ribo- and deoxyribonucleotides. Inhibits DNA and RNA synthesis and interfers with ribosomal protein synthesis. Displays antifungal and antitumor activity. Lately with the development of gene therapy, it has been introduced as a prodrug in combination with the cytosine deaminase suicide gene as antitumor compound, significantly improving survival and reducing tumor size in selected tumors.
Product References
(1) R.J. Holt & R.L. Newman; J. Clin. Pathol. 26, 167 (1973) | (2) R.B. Diasio, et al.; Biochem. Pharmacol. 27, 703 (1978) | (3) D.G. Osterman, et al.; Biochemistry 27, 5204 (1988) | (4) T. Ichikawa, et al.; Cancer Gene Ther. 7, 74 (2000) | (5) C. Fuerer & R. Iggo; Gene Ther. 11, 142 (2004) | (6) K. Kurozumi, et al.; J. Neurooncol. 66, 117 (2004)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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