Adipogen/3-Methyladenine/AG-CR1-3597-M100/100 mg
商品编号：
AG-CR1-3597-M100
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 3-MA;3MeA;6-Amino-3-methylpurine;NSC66389 |
| ProductType | Chemical |
| Properties | |
| Formula | C6H7N5 |
| MW | 149.2 |
| CAS | 5142-23-4 |
| RTECS | AU6520000 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,DMF,ethanolorwater. |
| InChiKey | FSASIHFSFGAIJM-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentcellpermeableandselectiveinhibitorofphosphatidyl-inositol3-kinase(PI3K)[1,7,8].
- BlocksclassI,classIIandclassIIIPI3Ks,includingsomedownstreamtargets[8].
- BlocksclassIPI3KpersistentlyandclassIIIPI3Ktransiently[7].
- Inducesautophagyundernutrient-richconditionsandinhibitsstarvation-inducedautophagyduetodifferentialeffectsonclassIversusclassIIIPI3kinase[5,7].
- ShowssomelimitedVps34preferenceinvitrocomparedtoPtdIns3Kγ.However,itistypicallyemployedincellularstudiesataconcentrationof10mM,whichcaninhibitallPtdIns3Ks[8].
- Cantargetotherkinasesandaffectothercellularprocesses,suchasglycogenmetabolism,lysosomalacidification,endocytosisandmitochondrialpermeabilitytransition[2-4].
- Anticancercompound[6,10,12].
- Neuroprotective[9,11].
- PKA-activationdependentlipolyticagent.EnhancesATGL-dependenthydrolysisoftriacylglycerols[13].
ProductReferences
- 3-Methyladenine:specificinhibitorofautophagic/lysosomalproteindegradationinisolatedrathepatocytes:P.O.Seglen&P.B.Gordon;PNAS79,1889(1982)
- 3-Methyladenine,aninhibitorofautophagy,hasmultipleeffectsonmetabolism:L.H.Caro,etal.;Eur.J.Biochem.175,325(1988)
- 3-Methyladenineinhibitstransportfromlateendosomestolysosomesinculturedratandmousefibroblasts:E.L.Punnonen,etal.;Eur.J.CellBiol.65,14(1994)
- Inhibitionofmitochondrialpermeabilitytransitionandreleaseofcytochromecbyanti-apoptoticnucleosideanalogues:L.Xue,etal.;Biochem.Pharmacol.64,441(2002)
- 3-methyladenineinhibitsautophagyintobaccoculturecellsundersucrosestarvationconditions:C.Takatsuka,etal.;PlantCellPhysiol.45,265(2004)
- 3-MethyladeninesuppressescellmigrationandinvasionofHT1080fibrosarcomacellsthroughinhibitingphosphoinositide3-kinasesindependentlyofautophagyinhibition:S.Ito,etal.;Int.J.Oncol.31,261(2007)
- Dualroleof3-methyladenineinmodulationofautophagyviadifferenttemporalpatternsofinhibitiononclassIandIIIphosphoinositide3-kinase:Y.T.Wu,etal.;J.Biol.Chem.285,10850(2010)
- FindingafittingshoeforCinderella:searchingforanautophagyinhibitor:S.Miller,etal.;Autophagy6,805(2010)
- Severeglobalcerebralischemia-inducedprogrammednecrosisofhippocampalCA1neuronsinratispreventedby3-methyladenine:awidelyusedinhibitorofautophagy:J.Y.Wang,etal.;J.Neuropathol.Exp.Neurol.70,314(2011)
- Inhibitorsofphosphatidylinositol3"-kinasespromotemitoticcelldeathinHeLacells:H.Hou,etal.;PLoSOne7,e35665(2012)
- Autophagyactivationisassociatedwithneuroprotectionagainstapoptosisviaamitochondrialpathwayinaratmodelofsubarachnoidhemorrhage:C.H.Jing,etal.;Neuroscience213,144(2012)
- 3-Methyladenineinducescelldeathanditsinteractionwithchemotherapeuticdrugsisindependentofautophagy:Y.Sheng,etal.;BBRC432,5(2013)
- Theautophagicinhibitor3-methyladeninepotentlystimulatesPKA-dependentlipolysisinADIpocytes:B.L.Heckmann,etal.;Br.J.Pharmacol.168,163(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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