Adipogen/3-Aminoisobutyric acid/AG-CR1-3596-G001/1 g
商品编号：
AG-CR1-3596-G001
品牌：
Adipogen Inc
市场价：
¥1900.00
美元价：
1140.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | β-Aminoisobutyricacid;BAIBA;3-Amino-2-methylpropanoicacid;DL-3-Aminoisobutyricacid;α-Methyl-β-alanine;3-Aminoisobutanoate;3-Aminoisobutyrate |
| ProductType | Chemical |
| Properties | |
| Formula | C4H9NO2.H2O |
| MW | 103.1.18.0 |
| CAS | 214139-20-5and144-90-1(anhydrous) |
| PurityChemicals | ≥98%(TLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSOorwater. |
| InChiKey | QCHPKSFMDHPSNR-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cataboliteofthymine[1-4].
- Precursorfor3-Hydroxyisobutyricacidsynthesis[3].
- Smallmoleculemyokine.BrowninginducerofwhiteADIposetissue(WAT)intobrownadiposetissue(BAT)[9,10].
- PGC-1α-mediatedandexercise-triggerednonadrenergicactivatoroftheThermogenicprograminWAT.Increasestheexpressionofbrownadipocyte-specificgenes(browning)inwhiteadipocytesandβ-oxidationinhepatocytesthroughaPPARα-mediatedmechanism[9,10].
- Inducesabrownadipose-likephenotypeinhumanpluripotentstemcellsandimprovesglucosehomeostasis[9,10].
- Enhancesfattyacidoxidationandreducesbodyweightinmicethroughanincreasedproductionofleptinbythewhiteadiposetissue(WAT)[5-7].
- InhibitsAgxt2-mediatedmetabolismofdimethylarginines[8].
- PartialagoNISToftheglycinereceptor(GlyR)[4].
ProductReferences
- beta-Aminoisobutyricacid(alpha-methyl-beta-alanine);anewamino-acidobtainedfromhumanurine:H.R.Crumpler,etal.;Nature167,307(1951)
- beta-aminoisobutyricacid,anewprobeforthemetabolismofDNAandRNAinnormalandtumoroustissue:H.R.Nielsen,etal.;CancerRes.34,1381(1974)
- Metabolismofthymineintumortissue:theoriginsofbeta-aminoisobutyricacid:B.S.Baliga&E.Borek;Adv.EnzymeRegul.13,27(1975)
Accumulationof3-hydroxyisobutyricacid,2-methyl-3-hydroxybutyricacidand3-hydroxyisovalericacidinketoacidosis:S.Landaas;Clin.Chim.Acta64,143(1975) - Pharmacologyoftheinhibitoryglycinereceptor:agonistandantagonistactionsofaminoacidsandpiperidinecarboxylicacidcompounds:V.Schmieden&H.Betz;Mol.Pharmacol.48,919(1995)
- Effectsofzidovudine,stavudineandbeta-aminoisobutyricacidonlipidhomeostasisinmice:possIBLeroleinhumanfatwasting:C.Maisonneuve,etal.;Antivir.Ther.9,801(2004)
- Beta-aminoisobutyricacidpreventsdiet-inducedobesityinmicewithpartialleptindeficiency:K.Begriche,etal.;Obesity(SilverSpring)16,2053(2008)
- Effectsofbeta-aminoisobutyricacidonleptinproductionandlipidhomeostasis:mechanismsandpossiblerelevanceforthepreventionofobesity:K.Begriche,etal.;Fundam.Clin.Pharmacol.24,269(2010)
- InvivoevidencethatAgxt2canregulateplasmalevelsofdimethylargininesinmice:A.Kittel,etal.;BBRC430,84(2013)
- beta-Aminoisobutyricacidinducesbrowningofwhitefatandhepaticbeta-oxidationandisinverselycorrelatedwithcardiometabolicriskfactors:L.D.Roberts,etal.;CellMetab.19,96(2014)
- ComeonBAIBAlightmyfire:H.L.Kammon&M.Febbraio;CellMetab.19,1(2014)(Review)
- BAIBAattenuatesinsulinresistanceandinflammationinducedbypalmitateorahighfatdietviaanAMPK–PPARδ-dependentpathwayinmice:TW.Jung,etal.;Diabetologia58,2096(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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