Adipogen/20-Hydroxyecdysone/AG-CN2-0072-M010/10 mg
商品编号：
AG-CN2-0072-M010
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | β-Ecdysone; Ecdysterone; BRN 1917578 ; NSC 629484; Commisterone; Crustecdyson; Polypodine A; 2β,3β,14α,20R,22R,25-Hexahydroxy-5β-cholest-7-en-6-one |
| Product Type | Chemical |
| Properties | |
| Formula | C27H44O7 |
| MW | 480.6 |
| Merck Index | 14: 3491 |
| CAS | 5289-74-7 |
| Source/Host Chemicals | Isolated from Ipomoea hederacea. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in water, ethanol, methanol, DMSO or acetic acid. |
| Identity | Identity determined by 1H-NMR. |
| InChi Key | NKDFYOWSKOHCCO-MQMWGCQISA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- A member of the ecdysteroid family.
- Ecdysone receptor (EcR) agonist. More potent than ecdysone.
- Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes.
- Plays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP).
- Regulates lipolysis in insects.
- Appears in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects.
- Used for controlled gene expression in scientific research, agriculture and medicine.
- Used for the development of selective insect growth regulators for use as environmentally benign insecticides.
- Shows biological effects on mammalian species.
- Neurosteroid. Antiepileptic. Acts on the modulatory site of the GABAA receptor and potentiates GABAergic inhibition in rat.
- Was shown to stimulate and modulate neutrophil production.
- Antidiabetic and antiobesity. Could be used as a nutritional supplement for the prevention and treatment of obesity and obesity-associated disorders.
- May protect PC12 cells against CoCl(2)-induced cell injury by inhibiting ROS production and modulating components of the mitochondrial apoptosis pathway.
- Does not have potent anabolic properties, however, a muscle-specific increase is observed and genes are identified to provide an explanation for the muscle accretion.
- Potential fibrosis antagonist for renal proximal tubule cells. Acts through suppressing post-receptor signaling of TGF-β1 and blocking the expression of Snail.
Product References
- 20-hydroxyecdysone, what it can do: F. Engelmann; Science 174, 1041 (1971)
- Relationship between 'early' and 'late' protein induced by 20-hydroxyecdysone in imaginal wing discs of Drosophila melanogaster: F.Y. Sin; Mol. Biol. Rep. 12, 7 (1987)
- Potentiation of GABA-induced inhibition by 20-hydroxyecdysone, a neurosteroid, in cultured rat cortical neurons: S. Tsujiyama, et al.; Jpn. J. Pharmacol. 68, 133 (1995)
- Ecdysone signaling cascade and regulation of Drosophila metamorphosis: E.H. Baehrecke, et al.; Arch. Insect Biochem. Physiol. 33, 231 (1996)
- Antiepileptic effects of 20-hydroxyecdysone on convulsive seizures in spontaneously epileptic rats: R. Hanaya, et al.; Jpn. J. Pharmacol. 74, 331 (1997)
- 20-hydroxyecdysone as a human lymphocyte and neutrophil modulator: In vitro evaluation: D.S. Trenin & V.V. Volodin; Arch. Insect Biochem. Physiol. 41, 156 (1999)
- Ecdysone receptors and their biological actions: L.M. Riddiford, et al.; Vitam. Horm. 60, 1 (2000)
- Ecdysone-regulated puff genes 2000: C.S Thummel; Insect Biochem. Mol. Biol. 32, 113 (2002)
- Ecdysone-controlled expression of transgenes: L.D. Graham; Expert Opin. Biol. Ther. 2, 525 (2002)
- Non-genomic ecdysone effects and the invertebrate nuclear steroid hormone receptor EcR--new role for an "old" receptor? U. Schlattner, et al.; Mol. Cell Endocrinol. 247, 64 (2006)
- 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model: P. Kizelsztein, et al.; Am. J. Physiol. Endocrinol. Metab. 296, E433 (2009)
- 20-hydroxyecdysone reduces insect food consumption resulting in fat body lipolysis during molting and pupation: S. Wang, et al.; J. Mol. Cell Biol. 2, 128 (2010)
- Protective effects of 20-hydroxyecdysone on CoCl(2)-induced cell injury in PC12 cells: J. Hu, et al.; J. Cell Biochem. 111, 1512 (2010)
- Quinoa extract enriched in 20-hydroxyecdysone protects mice from diet-induced obesity and modulates adipokines expression: A.S. Foucault, et al.; Obesity 20, 270 (2012)
- Continuous Infusion of 20-Hydroxyecdysone Increased Mass of Triceps Brachii in C57BL/6 Mice: D.M. Cheng, et al.; Phytother. Res. 27, 107 (2013)
- 20-hydroxyecdysone attenuates TGF-β1-induced renal cellular fibrosis in proximal tubule cells: T.J. Hung, et al.; J. Diabetes Complications 26, 463 (2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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