Adipogen/20-Hydroxyecdysone/AG-CN2-0072-M005/5 mg
商品编号：
AG-CN2-0072-M005
品牌：
Adipogen Inc
市场价：
¥1160.00
美元价：
696.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | β-Ecdysone;Ecdysterone;BRN1917578;NSC629484;Commisterone;Crustecdyson;PolypodineA;2β,3β,14α,20R,22R,25-Hexahydroxy-5β-cholest-7-en-6-one |
| ProductType | Chemical |
| Properties | |
| Formula | C27H44O7 |
| MW | 480.6 |
| MerckIndex | 14:3491 |
| CAS | 5289-74-7 |
| Source/HostChemicals | IsolatedfromIpomoeahederacea. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Whitesolid. |
| Solubility | Solubleinwater,ethanol,methanol,DMSOoraceticacid. |
| Identity | Identitydeterminedby1H-NMR. |
| InChiKey | NKDFYOWSKOHCCO-MQMWGCQISA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Amemberoftheecdysteroidfamily.
- Ecdysonereceptor(EcR)agoNIST.Morepotentthanecdysone.
- Inducestheexpressionofgenescodingforproteinsthatthelarvarequires,anditcauseschromosomepuffs(sitesofhighexpression)toforminpolytenechromosomes.
- Playsakeyroleininsectdevelopment,cellproliferaton,growthandapoptosisbycontrollinggeneexpressioninvolvedinmoultingandmetamorphosis.Itactsthroughaheterodimericreceptorcomprisingtheecdysonereceptorandtheultraspiracleproteins(USP).
- Regulateslipolysisininsects.
- Appearsinmanyplantsmostlyasaprotectionagent(toxinsorantifeedants)againstherbivorousinsects.
- Usedforcontrolledgeneexpressioninscientificresearch,agricultureandmedicine.
- Usedforthedevelopmentofselectiveinsectgrowthregulatorsforuseasenvironmentallybenigninsecticides.
- ShowsBIOLOGicaleffectsonmammalianspecies.
- Neurosteroid.Antiepileptic.ActsonthemodulatorysiteoftheGABAAreceptorandpotentiatesGABAergicinhibitioninrat.
- Wasshowntostimulateandmodulateneutrophilproduction.
- Antidiabeticandantiobesity.Couldbeusedasanutritionalsupplementforthepreventionandtreatmentofobesityandobesity-associateddisorders.
- MayprotectPC12cellsagainstCoCl(2)-inducedcellinjurybyinhibitingROSproductionandmodulatingcomponentsofthemitochondrialapoptosispathway.
- Doesnothavepotentanabolicproperties,however,amuscle-specificincreaseisobservedandgenesareidentifiedtoprovideanexplanationforthemuscleaccretion.
- Potentialfibrosisantagonistforrenalproximaltubulecells.Actsthroughsuppressingpost-receptorsignalingofTGF-β1andblockingtheexpressionofSnail.
ProductReferences
- 20-hydroxyecdysone,whatitcando:F.Engelmann;Science174,1041(1971)
- Relationshipbetween"early"and"late"proteininducedby20-hydroxyecdysoneinimaginalwingdiscsofDrosophilamelanogaster:F.Y.Sin;Mol.Biol.Rep.12,7(1987)
- PotentiationofGABA-inducedinhibitionby20-hydroxyecdysone,aneurosteroid,inculturedratcorticalneurons:S.Tsujiyama,etal.; Jpn.J.Pharmacol.68,133(1995)
- EcdysonesignalingcascadeandregulationofDrosophilametamorphosis:E.H.Baehrecke,etal.;Arch.InsectBiochem.Physiol.33,231(1996)
- Antiepilepticeffectsof20-hydroxyecdysoneonconvulsiveseizuresinspontaneouslyepilepticrats:R.Hanaya,etal.;Jpn.J.Pharmacol.74,331(1997)
- 20-hydroxyecdysoneasahumanlymphocyteandneutrophilmodulator:Invitroevaluation:D.S.Trenin&V.V.Volodin;Arch.InsectBiochem.Physiol.41,156(1999)
- Ecdysonereceptorsandtheirbiologicalactions:L.M.Riddiford,etal.;Vitam.Horm.60,1(2000)
- Ecdysone-regulatedpuffgenes2000:C.SThummel;InsectBiochem.Mol.Biol.32,113(2002)
- Ecdysone-controlledexpressionoftransgenes:L.D.Graham;ExpertOpin.Biol.Ther.2,525(2002)
- Non-genomicecdysoneeffectsandtheinvertebratenuclearsteroidhormonereceptorEcR--newroleforan"old"receptor?U.Schlattner,etal.;Mol.CellEndocrinol.247,64(2006)
- 20-Hydroxyecdysonedecreasesweightandhyperglycemiainadiet-inducedobesitymicemodel:P. Kizelsztein,etal.;Am.J.Physiol.Endocrinol.Metab.296,E433(2009)
- 20-hydroxyecdysonereducesinsectfoodconsumptionresultinginfatbodylipolysisduringmoltingandpupation:S.Wang,etal.;J.Mol.CellBiol.2,128(2010)
- Protectiveeffectsof20-hydroxyecdysoneonCoCl(2)-inducedcellinjuryinPC12cells:J.Hu,etal.;J.CellBiochem.111,1512(2010)
- Quinoaextractenrichedin20-hydroxyecdysoneprotectsmicefromdiet-inducedobesityandmodulatesADIpokinesexpression:A.S.Foucault,etal.;Obesity20,270(2012)
- ContinuousInfusionof20-HydroxyecdysoneIncreasedMassofTricepsBrachiiinC57BL/6Mice:D.M.Cheng,etal.;Phytother.Res.27,107(2013)
- 20-hydroxyecdysoneattenuatesTGF-β1-inducedrenalcellularfibrosisinproximaltubulecells:T.J.Hung,etal.;J.DiabetesComplications26,463(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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