Adipogen/2,5-Dimethyl-celecoxib/AG-CR1-3599-M005/5 mg
商品编号：
AG-CR1-3599-M005
品牌：
Adipogen Inc
市场价：
¥1200.00
美元价：
720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | DMC;2,5-Dimethylcelecoxib |
| ProductType | Chemical |
| Properties | |
| Formula | C18H16F3N3O2S |
| MW | 395.4 |
| CAS | 457639-26-8 |
| PurityChemicals | ≥99%(HPLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO,methanolordichloromethane. |
| InChiKey | NTFOSUUWGCDXEF-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Closestructuralanalogoftheselectivecyclooxygenase-2(COX-2)inhibitorcelecoxib,thatlacksCOX-2inhibitoryfunction.
- Anti-proliferative,anti-tumOrigenicandanti-angiogenic.
- Potentapoptosisinducerinmanycancercelllines.
- Down-regulatestheexpressionofsurvivin,cyclins,MMPsandinhibitscyclin-dependentkinaseactivity.
- ModulatesPDK-1,AKT,GSK3β,p70S6K,PKAandMAPKAP-K1α.
- ReducesphosphorylationofERK1/2butnotAKTT-308orAKTS-473.
- Increasesintracellularfreecalciumlevelsandpotentlytriggerstheendoplasmaticreticulumstressresponse(ESR),activatingERstress-associatedproteinsGRP78/BiP,CHOP/GADD153andcaspase-4.
ProductReferences
- Dimethyl-celecoxib(DMC),aderivativeofcelecoxibthatlackscyclooxygenase-2-inhibitoryfunction,potentlymimicstheanti-tumoreffectsofcelecoxibonBurkitt"slymphomainvitroandinvivo:A.Kardosh,etal.;CancerBiol.Ther.4,571(2005)
- DMC:novelcelecoxibderivativestorapcancer:P.Dent,etal.;CancerBiol.Ther.4,583(2005)
- Multitargetinhibitionofdrug-resistantmultiplemyelomacelllinesbydimethyl-celecoxib(DMC),anon-COX-2inhibitoryanalogofcelecoxib:A.Kardosh,etal.;Blood106,4330(2005)
- Calcium-activatedendoplasmicreticulumstressasamajorcomponentoftumorcelldeathinducedby2,5-dimethyl-celecoxib,anon-coxibanalogueofcelecoxib:P.Pyrko,etal.;Mol.CancerTher.6,1262(2007)
- Aggravatedendoplasmicreticulumstressasabasisforenhancedglioblastomacellkillingbybortezomibincombinationwithcelecoxiboritsnon-coxibanalogue,2,5-dimethyl-celecoxib:A.Kardosh,etal.;CancerRes.68,843(2008)
- DimethylcelecoxibinhibitsmPGES-1promoteractivitybyinfluencingEGR1andNF-κB:K.Deckmann,etal.;Biochem.Pharmacol.80,1365(2010)
- Antiangiogenicactivitiesof2,5-dimethyl-celecoxibonthetumorvasculature:J.J.Virrey,etal.;Mol.CancerTher.9,631(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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