Adipogen/17-DMAG/BVT-0255-C100/100 µg
商品编号：
BVT-0255-C100
品牌：
Adipogen Inc
市场价：
¥600.00
美元价：
360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NSC707545;17-[2-(Dimethylamino)ethyl]amino-17-desmethoxygeldanamycin |
| ProductType | Chemical |
| Properties | |
| Formula | C32H48N4O8 |
| MW | 616.8 |
| CAS | 467214-20-6 |
| Source/HostChemicals | Semi-syntheticderivativefromgeldanamycin. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Purpletoblackpowder. |
| Solubility | Solubleinwater,100%ethanol(10mg/ml)orDMSO(>25mg/ml) |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | KUFRQPKVAWMTJO-LMZWQJSESA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Lesstoxic,morepotentsyntheticderivativeofgeldanamycin(Prod.No.BVT-0196).
- Angiogenesisinhibitor.
- Heatshockprotein90(HSP90)inhibitor.
- Apoptosisinducer.
- Showshigherantitumoractivitythan17-AAG(Prod.No.BVT-0244).
ProductReferences
- Pharmacokinetics,tissuedistribution,andmetabolismof17-(dimethylaminoethylamino)-17-demethoxygeldanamycin(NSC707545)inCD2F1miceandFischer344rats:M.J.Egorin,etal.;CancerChemother.Pharmacol.49,7(2002)
- Biliaryexcretionof17-(allylamino)-17-demethoxygeldanamycin(NSC330507)andmetabolitesbyFischer344rats:S.M.Musser,etal.;CancerChemother.Pharmacol.52,139(2003)
- Crystalstructureandmolecularmodelingof17-DMAGincomplexwithhumanHsp90:J.M.Jez,etal.;Chem.Biol.10,361(2003)
- Antiangiogenicpropertiesof17-(dimethylaminoethylamino)-17-demethoxygeldanamycin:anorallybioavailableheatshockprotein90modulator:G.Kaur,etal.;Clin.CancerRes.10,4813(2004)
- EnhancedtumorcellrADIosensitivityandabrogationofG2andSphasearrestbytheHsp90inhibitor17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin:E.E.Bull,etal.;Clin.CancerRes.10,8077(2004)
- SynthesisandBIOLOGicalactivitiesofnovel17-aminogeldanamycinderivatives:Z.Q.Tian,etal.;Bioorg.Med.Chem.12,5317(2004)
- Comparisonof17-dimethylaminoethylamino-17-demethoxy-geldanamycin(17DMAG)and17-allylamino-17-demethoxygeldanamycin(17AAG)invitro:effectsonHsp90andclientproteinsinmelanomamodels:V.Smith,etal.;CancerChemother.Pharmacol.56,126(2005)
- Invivoantitumorefficacyof17-DMAG(17-dimethylaminoethylamino-17-demethoxygeldanamycinhydrochloride),awater-solublegeldanamycinderivative:M.Hollingshead,etal.;CancerChemother.Pharmacol.56,115(2005)
- Preclinicaltoxicityofageldanamycinanalog,17-(dimethylaminoethylamino)-17-demethoxygeldanamycin(17-DMAG),inratsanddogs:potentialclinicalrelevance:E.R.Glaze,etal.;CancerChemother.Pharmacol.56,637(2005)
- Structure-baseddesignof7-carbamateanalogsofgeldanamycin:G.Rastelli,etal.;Biooorg.Med.Chem.Lett.15,5016(2005)
- Determinationoftheheatshockprotein90inhibitor17-dimethylaminoethylamino-17-demethoxygeldanamycininplasmabyliquidchromatography-electrospraymassspectrometry:K.Hwang,etal.;J.Chromatogr.BAnalyt.Technol.Biomed.LifeSci.830,35(2006)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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