Adipogen/17-AAG/BVT-0244-M025/25 mg
商品编号：
BVT-0244-M025
品牌：
Adipogen Inc
市场价：
¥2400.00
美元价：
1440.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 17-(Allylamino)-17-desmethoxygeldanamycin |
| ProductType | Chemical |
| Properties | |
| Formula | C31H43N3O8 |
| MW | 585.7 |
| CAS | 75747-14-7 |
| Source/HostChemicals | Semi-syntheticderivativefromgeldanamycin. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Redtodarkredpowder. |
| Solubility | SolubleinDMSO(10mg/ml)ormethanol(10mg/ml). |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | AYUNIORJHRXIBJ-DDSLGTNESA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,lesstoxicanalogofgeldanamycin(Prod.No.BVT-0196).
- InhibitstheessentialATPaseactivityofHSP90.
- Telomeraseactivityinhibitor.
- Apoptosisinducer.
- Antitumorcompound.
ProductReferences
- Inhibitionoftheoncogeneproductp185erbB-2invitroandinvivobygeldanamycinanddihydrogeldanamycinderivatives:R.C.Schnur,etal.;J.Med.Chem.38,3806(1995)
- Thebenzoquinoneansamycin17-allylamino-17-demethoxygeldanamycinbindstoHSP90andsharesimportantBIOLOGicactivitieswithgeldanamycin:T.W.Schulte&L.M.Neckers;CancerChemother.Pharmacol.42,273(1998)
- Geneexpressionprofilingofhumancoloncancercellsfollowinginhibitionofsignaltransductionby17-allylamino-17-demethoxygeldanamycin,aninhibitorofthehsp90molecularchaperone:P.A.Clarke,etal.;Oncogene19,4125(2000)
- Geldanamycinanditsanalogue17-allylamino-17-demethoxygeldanamycinlowersBcr-AbllevelsandinducesapoptosisanddifferentiationofBcr-Abl-positivehumanleukemicblasts:R.Nimmanapalli,etal.;CancerRes.61,1799(2001)
- Ahigh-affinityconformationofHsp90conferstumourselectivityonHsp90inhibitors:A.Kamal,etal.;Nature425,407(2003)
- Geldanamycinandits17-allylamino-17-demethoxyanalogueantagonizetheactionofCisplatininhumancolonadenocarcinomacells:differentialcaspaseactivationasabasisforinteraction:I.A.Vasilevskaya,etal.;CancerRes.63,3241(2003)
- Inhibitionoftelomeraseactivitybygeldanamycinand17-allylamino,17-demethoxygeldanamycininhumanmelanomacells:R.Villa,etal.;Carcinogenesis24,851(2003)
- IntratumorinjectionoftheHsp90inhibitor17AAGdecreasestumorgrowthandinducesapoptosisinaprostatecancerxenograftmodel:C.R.Williams,etal.;J.Urol.178,1528(2007)
- PhaseIandpharmacodynamicstudyof17-(allylamino)-17-demethoxygeldanamycininadultpatientswithrefractoryadvancedcancers:R.K.Ramanathan,etal.;Clin.CancerRes.13,1769(2007)
- Aninvitroandinvivostudyofthecombinationoftheheatshockproteininhibitor17-allylamino-17-demethoxy-geldanamycinandcarboplatininhumanovariancancermodels:U.Banerji,etal.;CancerChemother.Pharmacol.62,769(2008)
- HSP90inhibitor17AAGcausesapoptosisinATRA-resistantacutepro-myelocyticleukemiacells:P.N.Meyer,etal.;Leuk.Res.32,143(2008)
- Heatshockprotein90inhibitorsattenuateinflammatoryresponsesinatherosclerosis:J.Madrigal-Matute,etal.;CardiovascularRes.86,330(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
