Adipogen/1400W . dihydrochloride/AG-CR1-0018-M025/25 mg
商品编号：
AG-CR1-0018-M025
品牌：
Adipogen Inc
市场价：
¥2800.00
美元价：
1680.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | N-(3-(Aminomethyl)benzyl)acetamidine.2HCl |
| ProductType | Chemical |
| Properties | |
| Formula | C10H15N3.2HCl |
| MW | 177.3.72.9 |
| CAS | 214358-33-5 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solubleinwater,methanolorDMSO. |
| InChiKey | WDJHSQZCZGPGAA-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Hygroscopic. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Aslow,tightbindingandhighlyselectiveinhibitorofiNOS(inducIBLenitricoxidesynthase/NOSII)(Kd≤7nM)[1,3,4,6].
- WeakandreversibleinhibitionofnNOS(neuronalnitricoxidesynthase/NOSI)(Ki≤2)andeNOS(endothelialnitricoxidesynthase/NOSIII)(Ki≤50μM)[1].
- Inhibitstumorgrowth[2].
- Increasesvasoconstrictiontonoradrenaline[7].
- Improvescontractilefunction[8].
- Improvesstrokeoutcomeanddecreasesglutamaterelease[9].
- Anti-inflammatory[10].
- SignificantAMPKactivitysuppressor.
- Review[5].
ProductReferences
- 1400Wisaslow,tightbinding,andhighlyselectiveinhibitorofinduciblenitric-oxidesynthaseinvitroandinvivo:E.P.Garvey,etal.;J.Biol.Chem.272,4959(1997)
- Selectiveinhibitionofinduciblenitricoxidesynthaseinhibitstumorgrowthinvivo:studieswith1400W,anovelinhibitor:L.L.Thomsen,etal.;CancerRes.57,3300(1997)
- Actionsofisoform-selectiveandnon-selectivenitricoxidesynthaseinhibitorsonendotoxin-inducedvascularleakageinratcolon:F.Laszlo&B.J.R.Whittle;Eur.J.Pharmacol.334,99(1997)
- Theinhibitorypotencyandselectivityofargininesubstratesitenitric-oxidesynthaseinhibitorsissolelydeterminedbytheiraffinitytowardthedifferentisoenzymes:R.Boer,etal.;Mol.Pharmacol.58,1026(2000)
- Nitricoxidesynthases:structure,functionandinhibition:W.K.Alderton,etal.;Biochem.J.357,593(2001)
- Structuralbasisforthespecificityofthenitric-oxidesynthaseinhibitorsW1400andNomega-propyl-L-Argfortheinducibleandneuronalisoforms:R.Fedorov,etal.;J.Biol.Chem.278,45818(2003)
- Increasedvasoconstrictiontonoradrenalineby1400W,inhibitorofiNOS,inratswithstreptozotocin-induceddiabetes:X.Cheng&C.C.Pang;Eur.J.Pharmacol.484,263(2004)
- InhibitionofiNOSwith1400Wimprovescontractilefunctionandaltersnosgeneandproteinexpressioninreperfusedskeletalmuscle:P.Patel,etal.;Microsurgery24,324(2004)
- InhibitionofiNOSactivityby1400Wdecreasesglutamatereleaseandamelioratesstrokeoutcomeafterexperimentalischemia:F.J.Perez-Asensio,etal.;Neurobiol.Dis.18,375(2005)
- SelectiveiNOSinhibitor1400Wenhancesanti-catabolicIL-10andreducesdestructiveMMP-10inOAcartilage.Surveyoftheeffectsof1400WoninflammatorymediatorsproducedbyOAcartilageasdetectedbyproteinantibodyarray:K.Järvinen,etal.;Clin.Exp.Rheumatol.26,275(2008)
- GlucoseMetabolismandAMPKSignalingRegulateDopaminergicCellDeathInducedbyGene(α-Synuclein)-Environment(Paraquat)Interactions:A.Anandhan,etal.;Mol.Neurobiol.54,3825(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
