Adipogen/10Z-Hymenialdisine/AG-CN2-0067-M001/1 mg
商品编号：
AG-CN2-0067-M001
品牌：
Adipogen Inc
市场价：
¥6400.00
美元价：
3840.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Hymenialdisine;4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one |
| ProductType | Chemical |
| Properties | |
| Formula | C11H10BrN5O2 |
| MW | 324.1 |
| CAS | 82005-12-7 |
| Source/HostChemicals | IsolatedfromspongeAxinellacarteri. |
| PurityChemicals | ≥97%(HPLC)(Containstracesofthe10E-isomer) |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | ATBAETXFFCOZOY-DAXSKMNVSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Keepunderinertgas. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Insecticidalandcytotoxic[1].
- PotentNF-κBinhibitor.Inhibitsvariouspro-inflammatorycytokinessuchasIL-1,IL-2,IL-6,IL-8,TNF-αandnitricoxide(NO)inavarietyofcelllines[2,3,4,9].
- ATP-competitivekinaseinhibitor.InhibitsDNAdamagecheckpointatG2,cyclin-dependentkinasesCDK1/cyclinB,CDK2/cyclinA,CDK2/cyclinE,CDK4/cyclinD1,CDK5/p25,GSK-3βandcaseinkinase1(CK1)[5,6].
- Potentmitogen-activatedproteinkinasekinase-1(MEK-1)inhibitor[7].
- MARK(microtubuleaffinity-regulatingkinase)inhibitor[8].
ProductReferences
- BioactivealkaloidsfromthetropicalmarinespongeAxinellacarteri:A.Supriyono,etal.;Z.Naturforsch.[C]50,669(1995)
- Thenaturalproducthymenialdisineinhibitsinterleukin-8productioninU937cellsbyinhibitionofnuclearfactor-kappaB:J.J.Breton&M.C.Chabot-Fletcher;J.Pharmacol.Exp.Ther.282,459(1997)
- InhibitionofNFkappaB-mediatedinterleukin-1beta-stimulatedprostaglandinE2formationbythemarinenaturalproducthymenialdisine:A.Roshak,etal.;J.Pharmacol.Exp.Ther.283,955(1997)
- Inhibitionofinterleukin-1-inducedproteoglycandegradationandnitricoxideproductioninbovinearticularcartilage/chondrocyteculturesbythenaturalproduct,hymenialdisine:A.M.Badger,etal.;J.Pharmacol.Exp.Ther.290,587(1999)
- Inhibitionofcyclin-dependentkinases,GSK-3betaandCK1byhymenialdisine,amarinespongeconstituent:L.Meijer,etal.;Chem.Biol.7,51(2000)
- InhibitionoftheG2DNAdamagecheckpointandofproteinkinasesChk1andChk2bythemarinespongealkaloiddebromohymenialdisine:D.Curman,etal.;J.Biol.Chem.276,17914(2001)
- AldisinealkaloidsfromthePhilippinespongeStylissamassaarepotentinhibitorsofmitogen-activatedproteinkinasekinase-1(MEK-1):D.Tasdemir,etal.;J.Med.Chem.45,529(2002)
- ProteinkinaseMARK/PAR-1isrequiredforneuriteoutgrowthandestablishmentofneuronalpolarity:J.Biernatetal.;Mol.Biol.Cell.13,4013(2002)
- Inhibitionofcytokineproductionbyhymenialdisinederivatives:V.Sharma,etal.;J.Med.Chem.47,3700(2004)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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