脂肪素/（±）-维拉帕米。盐酸（USP级）/AG-CR1-3627-G005/5 g
商品编号：
AG-CR1-3627-G005
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NSC135784;NSC272366;NSC657799 |
| ProductType | Chemical |
| Properties | |
| Formula | C27H38N2O4.HCl |
| MW | 454.6.36.5 |
| CAS | 152-11-4 |
| RTECS | YV8320000 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥99%(NMR) |
| Appearance | Whitepowder. |
| Solubility | Solubleinmethanol(50mg/ml),ethanolorwater. |
| InChiKey | DOQPXTMNIUCOSY-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- α1-Adrenergicreceptor(α-AR)antagoNIST.
- PrototypicalcalciumchannelproteininhibitorthatblockstheL-typeCa2+channelsinsmoothandcardiacmusclecells.
- Vasodilatorknowntoreducetherenalclearanceofdigoxinandusedtocontrolhypertension,angina,cardiacarrhythmiaandvascularheadaches.
- Apoptosisinducerinprimaryandmetastaticcolonadenocarcinomahumancelllinesinvitro.
- InhibitorofdrugeffluxpumpproteinssuchasMdr(P-glycoprotein)whichareoftenover-expressedincertaintumorcelllines.
- SubstrateofCYP3A4andCYP2C6.
- UsedinfluorescentcellsortingforDNAcontent,asitblockseffluxofavarietyofDNA-bindingfluorophoressuchasHoechst33342.
- Anti-diabeticinanimalmodelsbylimitingTXNIPexpression.
ProductReferences
- Newantiarrhythmicagents:amiodarone,aprindine,disopyramide,ethmozin,mexiletine,tocainide,verapamil:D.P.Zipes&P.J.Troup;Am.J.Cardiol.41,1005(1978)(Review)
- alpha-adrenergicantagonistsaspossIBLecalciumchannelinhibitors:D.Atlas&M.Adler;PNAS78,1237(1981)
- Verapamilhydrochloride:pharmacologicalpropertiesandroleincardiovasculartherapeutics:S.H.Baky&B.N.Singh;Pharmacotherapy2,328(1982)(Review)
- Verapamil:fullspectrumcalciumchannelblockingagent:anoverview:J.R.Guerrero&S.S.Martin;Med.Res.Rev.4,87(1984)(Review)
- Thecalciumchannelblockerverapamilandcancerchemotherapy:W.G.Simpson;CellCalcium6,449(1985)(Review)
- Themechanismofactionofcalciumantagonistsrelativetotheirclinicalapplications:B.N.Singh;Br.J.Clin.Pharmacol.21,109S(1986)
- Enhancementofthemutagenicityofanticancerdrugsbythecalciumantagonistsverapamilandfendiline:W.Scheid,etal.;Arzneimittelforschung41,901(1991)(Review)
- Apoptosisofhumanprimaryandmetastaticcolonadenocarcinomacelllinesinvitroinducedby5-fluorouracil,verapamil,andhyperthermia:I.B.Shchepotin,etal.;AnticancerRes.14,1027(1994)
- ReversalofanovelmultidrugresistancemechanisminhumancoloncarcinomacellsbyfumitremorginC:S.K.Rabindran,etal.;CancerRes.58,5850(1998)
- Erythromycinandverapamilconsiderablyincreaseserumsimvastatinandsimvastatinacidconcentrations:T.Kantola,etal.;Clin.Pharmacol.Ther.64,177(1998)
- P-glycoproteinsystemasadeterminantofdruginteractions:thecaseofdigoxin-verapamil:M.Verschraagen,etal.;Pharmacol.Res.40,301(1999)
- Preventingβ-celllossanddiabeteswithcalciumchannelblockers:G.Xu,etal.;Diabetes61,848(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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