Adipogen/(S)-CR8/AG-MR-C0004-M010/10 mg
商品编号：
AG-MR-C0004-M010
品牌：
Adipogen Inc
市场价：
¥4000.00
美元价：
2400.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine |
| ProductType | Chemical |
| Properties | |
| Formula | C24H29N7O |
| MW | 431.5 |
| CAS | 1084893-56-0 |
| PurityChemicals | ≥99%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOorethanol. |
| Reconstitution | Stocksolutionscanbemadeupto10mMinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | HOCBJBNQIQQQGT-IBGZPJMESA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepunderinertgas. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentcyclin-dependentkinase(CDK)1,2,5,and9inhibitor[1,2].
- Apoptosisinducer[1,3,5].
- Inhibitstheproliferationofvariouscancercelllines[1].
- Inhibitscystsformationinculture[4].
- Caseinkinase1(CK1δ/ε)andDyrk1Ainhibitor[1].
- DownregulatesexpressionofMcl-1andMYCN.
- Neuroprotectiveinexperimentaltraumaticbraininjury.
- Potentialanti-inflammatorycompound.
- Potentialantidiabeticcompound.
ProductReferences
- CR8,apotentandselective,roscovitine-derivedinhibitorofcyclin-dependentkinases:K.Bettayeb,etal.;Oncogene27,5797(2008)
- Roscovitine-derived,dual-specificityinhibitorsofcyclin-dependentkinasesandcaseinkinases1:N.Oumata,etal.;J.Med.Chem.51,5229(2008)
- CDKinhibitorsroscovitineandCR8triggerMcl-1down-regulationandapoptoticcelldeathinneuroblastomacells:K.Bettayeb,etal.;GenesCancer1,369(2010)
- CDKinhibitorsR-roscovitineandS-CR8effectivelyblockrenalandhepaticcystogenesisinanorthologousmodelofADPKD:N.O.Bukanov,etal.;CellCycle11,4040(2012)
- CR8,aselectiveandpotentCDKinhibitor,providesneuroprotectioninexperimentaltraumaticbraininjury.S.V.KabADI,etal.;Neurotherapeutics9,405(2012)
- InhibitionofNF-κB-mediatedsignalingbythecyclin-dependentkinaseinhibitorCR8overcomesprosurvivalstimulitoinduceapoptosisinchroniclymphocyticleukemiacells:E.Cosimo,etal.;Clin.CancerRes.19,2393(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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