Adipogen/(R)-Roscovitine/AG-CR1-0006-M005/5 mg
商品编号：
AG-CR1-0006-M005
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine |
| ProductType | Chemical |
| Properties | |
| Formula | C19H26N6O |
| MW | 354.5 |
| CAS | 186692-46-6 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOor100%ethanol;onlymoderatelysolubleinwater. |
| InChiKey | BTIHMVBBUGXLCJ-OAHLLOKOSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentandselectiveinhibitorofCDKs[1,2,4,16].
- Morepotentthanolomoucine[3].
- InhibitsCDK1/cyclinBkinase(IC50=450nM)[2],CDK2(IC50=700nM)[4]andCDK5/p35(IC50=160nM)[4,5].
- InhibitsMphasepromotingfactor(MPF)kinaseactivity[2].
- ArrestshumanfibroblastsinG1phase[6].
- Antitumorcompound[8].
- Activatesthemitogen-activatedproteinkinasepathway[9].
- Targetsboththep53andNF-κBpathways[10].
- Haseffectsoncalciumchannelgating[12,17,18].
- PreventsDNAdamage-inducedcyclinA1upregulation[13].
- Apoptosisinducer[11,15,20].
- AsCYC202inphaseIclinicaltrials[14].
- Reviews[3,7,19].
ProductReferences
- Activationofcyclin-dependentkinasesbyMycmediatesinductionofcyclinA,butnotapoptosis:B.Rudolph,etal.;EMBOJ.15,3065(1996)
- Biochemicalandcellulareffectsofroscovitine,apotentandselectiveinhibitorofthecyclin-dependentkinasescdc2,cdk2andcdk5:L.Meijer,etal.;Eur.J.Biochem.243,527(1997)
- Chemicalinhibitorsofcyclin-dependentkinases:L.MeijerandS.H.Kim;Meth.Enzymol.283,113(1997)
- Cytokinin-derivedcyclin-dependentkinaseinhibitors:synthesisandcdc2inhibitoryactivityofolomoucineandrelatedcompounds:L.Havlicek,etal.;J.Med.Chem.40,408(1997)
- DirectinvivoinhibitionofthenuclearcellcyclecascadeinexperimentalmesangialproliferativeglomerulonephritiswithRoscovitine,anovelcyclin-dependentkinaseantagoNIST:J.W.Pippin,etal.;J.Clin.Invest.100,2512(1997)
- Thecyclin-dependentkinaseinhibitorsolomoucineandroscovitinearresthumanfibroblastsinG1phasebyspecificinhibitionofCDK2kinaseactivity:F.Alessi,etal.;Exp.CellRes.245,8(1998)
- Thespecificitiesofproteinkinaseinhibitors:anupdate:J.Bain,etal.;Biochem.J.371,199(2003)
- InvitroandinvivoantitumorpropertiesofthecyclindependentkinaseinhibitorCYC202(R-roscovitine):S.J.McClue,etal.;Int.J.Cancer102,463(2002)
- TheCyclin-dependentkinaseinhibitorCYC202(R-roscovitine)inhibitsretinoblastomaproteinphosphorylation,causeslossofCyclinD1,andactivatesthemitogen-activatedproteinkinasepathway:S.R.Whittaker,etal.;CancerRes.64,262(2004)
- R-Roscovitinesimultaneouslytargetsboththep53andNF-kappaBpathwaysandcausespotentiationofapoptosis:implicationsincancertherapy:A.Dey,etal.;CellDeathDiffer.15,263(2008)
- TheCDKinhibitor,R-roscovitine,promoteseosinophilapoptosisbydown-regulationofMcl-1:R.Duffin,etal.;FEBSLett.583,2540(2009)
- (R)-roscovitineprolongsthemeanopentimeofunitaryN-typecalciumchannelcurrents:N.R.DeStefino,etal.;Neuroscience167,838(2010)
- R-Roscovitine(Seliciclib)preventsDNAdamage-inducedcyclinA1upregulationandhindersnon-homologousend-joining(NHEJ)DNArepair:M.Federico,etal.;Mol.Cancer9,208(2010)
- PhaseIevaluationofseliciclib(R-roscovitine),anoveloralcyclin-dependentkinaseinhibitor,inpatientswithadvancedmalignancies:C.LeTourneau,etal.;Eur.J.Cancer46,3243(2010)
- Roscovitine,olomoucine,purvalanol:inducersofapoptosisinmaturingcerebellargranuleneurons:E.A.Monaco,3rd,etal.;Biochem.Pharmacol.67,1947(2004)
- Roscovitinetargets,proteinkinasesandpyridoxalkinase:S.Bach,etal.;J.Biol.Chem.280,31208(2005)
- Theeffectsofpresynapticcalciumchannelmodulationbyroscovitineontransmitterreleaseattheadultfrogneuromuscularjunction:S.Cho&S.D.Meriney;Eur.J.Neurosci.23,3200(2006)
- RoscovitinedifferentiallyaffectsCaV2andKvchannelsbybindingtotheopenstate:Z.Buraei,etal.;Neuropharmacology52,883(2007)
- Cyclin-dependentkinaseinhibitorsasanticancerdrugs:V.Krystof&S.Uldrijan;Curr.DrugTargets11,291(2010)
- RoscovitineinducescelldeathandmorphologicalchangesindicativeofapoptosisinMDA-MB-231breastcancercells:O.P.Mgbonyebi,etal.;CancerRes.59,1903(1999)
- Polo-likekinase4transcriptionisactivatedviaCREandNRF1elements,repressedbyDREAMthroughCDE/CHRsitesandderegulatedbyHPVE7protein:M.Fischer,etal.;NucleicAcidsRes.42,163(2014)(ADIpogenspec.)
- RoscovitineisaproteostasisregulatorthatcorrectsthetraffickingdefectofF508del-CFTRbyaCDK-independentmechanism:C.Norez,etal.;Br.J.Pharmacol.171,4831(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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