Adipogen/(R)-Roscovitine/AG-MR-C0001-M025/25 mg
商品编号：
AG-MR-C0001-M025
品牌：
Adipogen Inc
市场价：
¥3600.00
美元价：
2160.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Seliciclib;CYC201;6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine |
| ProductType | Chemical |
| Properties | |
| Formula | C19H26N6O |
| MW | 354.5 |
| CAS | 186692-46-6 |
| PurityChemicals | ≥99%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOorethanol.Slightlysolubleinwater. |
| Reconstitution | Stocksolutionscanbemadeupto10mMinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | BTIHMVBBUGXLCJ-OAHLLOKOSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentandselectiveinhibitorofcyclindependentkinasesCDK1,CDK2,CDK5,CDK7andCDK9.
- Pyridoxalkinase(PDXK)inhibitor.
- Triggerscellapoptoticcelldeath.
- Down-regulatesMcl-1andMYCN.
- Anticancercompound.Killschroniclymphocyticleukemia(LLC)cellsandslowstumorgrowthinmousexenografts.
- Inhibitscystsformationincultureandinpolycystickidneydisease(PKD)mousemodels.
- Potentialanti-inflammatorycompoundthatcaninfluencetheresolutionofinflammation.
- Potentialantidiabeticcompound.Showntoprotectpancreaticβ-cellsfromglucotoxicityandincreaseinsulinsecretion.
- Showsantiviralproperties.
- Neuroprotectiveinbraintrauma.
- HaspositiveeffectsonTimothysyndromecells.
- Usedforcloningofmammalsbysynchronizationofnucleusdonorcells.
- Providesneuroprotectioninexperimentaltraumaticbraininjury.
ProductReferences
- Biochemicalandcellulareffectsofroscovitine,apotentandselectiveinhibitorofthecyclin-dependentkinasescdc2,cdk2andcdk5:L.Meijer,etal.;Eur.J.Biochem.243,527(1997)
- Chemicalinhibitorsofcyclin-dependentkinases:L.MeijerandS.H.Kim;Meth.Enzymol.283,113(1997)
- Inhibitionofcyclin-dependentkinasesbypurineanalogues:crystalstructureofhumancdk2complexedwithroscovitine:WF.DeAzevedo,etal.;Eur.J.Biochem.243,518(1997)
- Pharmacologicalcyclin-dependentkinaseinhibitorsinhibitreplicationofwild-typeanddrug-resistantstrainsofHerpessimplexvirusandHumanimmunodeficiencyvirustype1bytargetingcellular,notviral,proteins:L.M.Schang,etal.;J.Virol.76,7874(2002)
- Enhancedsurvivabilityofclonedcalvesderivedfromroscovitine-treatedadultsomaticcells:J.Gibbons,etal.;Biol.Reprod.66,895(2002)
- Roscovitineandotherpurinesaskinaseinhibitors.Fromstarfishoocytestoclinicaltrials:L.Meijer&E.Raimond;Acc.Chem.Res.36,417(2003)
- Crystalstructureofpyridoxalkinaseincomplexwithroscovitineandderivatives:L.Tang,etal.;J.Biol.Chem.280,31220(2005)
- Roscovitinetargets,proteinkinasesandpyridoxalkinase:S.Bach,etal.;J.Biol.Chem.280,31208(2005)
- Inhibitionofcyclin-dependentkinase5activityprotectspancreaticbetacellsfromglucotoxicity:M.Ubeda,etal.;J.Biol.Chem.281,28858(2006)
- Cyclin-dependentkinaseinhibitorsenhancetheresolutionofinflammationbypromotinginflammatorycellapoptosis:A.G.Rossi,etal.;NatureMed.12,1056(2006)
- Long-lastingarrestofmurinepolycystickidneydiseasewithCDKinhibitorRoscovitine:N.O.Bukanov,etal.;Nature444,949(2006)
- Productionofclonedhorsefoalsusingroscovitine-treateddonorcellsandactivationwithspermextractand/orionomycin:K.Hinrichs,etal.;Reproduction134,319(2007)
- CR8,apotentandselective,roscovitine-derivedinhibitorofcyclin-dependentkinases:K.Bettayeb,etal.;Oncogene27,5797(2008)
- PracticalSynthesisofRoscovitineandCR8:N.Oumata,etal.;Org.ProcessRes.Dev.13,641(2009)
- CDKinhibitorsRoscovitineandCR8triggerMcl-1down-regulationandapoptoticcelldeathinneuroblastomacells:K.Bettayeb,etal.;Genes&Cancer1,369(2010)
- UsinginducedpluripotentstemcellstoinvestigatecardiacphenotypesinTimothysyndrome:M.Yazawa;Nature471,230(2011)
- CDKinhibitorsR-roscovitineandS-CR8effectivelyblockrenalandhepaticcystogenesisinanorthologousmodelofADPKD:N.O.Bukanov,etal.;CellCycle11,4040(2012)
- SelectiveCDKinhibitorlimitsneuroinflammationandprogressiveneurodegenerationafterbraintrauma:S.V.KabADI,etal.;J.Cereb.BloodFlowMetab.32,137(2012)
- RoscovitineisaproteostasisregulatorthatcorrectsthetraffickingdefectofF508del-CFTRbyaCDK-independentmechanism:C.Norez,etal.;Br.J.Pharmacol.171,4831(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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