Adipogen/(R)-FSL-1/AG-CP3-0010-C100/100 µg
商品编号：
AG-CP3-0010-C100
品牌：
Adipogen Inc
市场价：
¥5200.00
美元价：
3120.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Fibroblast-stimulatingLipopeptide;R-Pam2CGDPKHPKSF;(R)-Pam2Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH |
| ProductType | Chemical |
| Properties | |
| Formula | C84H140N14O18S |
| MW | 1666.2 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | AbsenceofdetectableproteinorDNAcontaminantswithagoNISTicTLRactivity. |
| Appearance | Colorlesspowder. |
| Solubility | Solubleinwater(10mg/ml).Useahomogeniserorsonicatortoprepareahomogenoussolution. |
| Reconstitution | Reconstitutein100μlendotoxin-freewater(Prod.No.IAX-900-002)togeta1mg/mlstocksolution. |
| Formulation | Lyophilized. |
| OtherProductData | Note:FSL-1stimulationinducesaMyD88-dependentsignalingcascadeleADIngtotheactivationofNF-κBandtheproductionofproinflammatorycytokines.FSL-1exhibitsahigherstimulatoryactivitythanMALP-2whentestedforitsABIlitytoinducetheproductionofTNF-αinmacrophagesandNF-κBinTLR2/TLR6transfectedHEK293cells.Dependingonthesensitivityoftheinvitroassay,therecommendedworkingconcentrationforspecificstimulationofinnateimmunityviaTLR2/TLR6heterodimersis10-100nM.FSL-1iswatersolubleincontrasttoMALP2. |
| InChiKey | VJJLLNHELGKSNA-QWIIDARVSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/Stability | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- R-FSL-1(R-Pam2CGDPKHPKSF)isasyntheticlipoproteinthatrepresentstheN-terminalpartofthe44kDalipoproteinLP44ofMycoplasmasalivarium[1].
- ThenaturallyoccurringR-stereoisomerisBIOLOGicallymoreactivethantheS-stereoisomer[4].
- StimulatorofTLR2/TLR6[2-13].
- InducerofTNF-αproductioninmacrophages[5].
- Upregulatesproinflammatorycytokines[3,5].
- ActivatoroftheproinflammatorytranscriptionfactorNF-κB[3].
ProductReferences
- TheN-terminallipopeptideofa44-kDamembrane-boundlipoproteinofMycoplasmasalivariumisresponsIBLefortheexpressionofintercellularadhesionmolecule-1onthecellsurfaceofnormalhumangingivalfibroblasts:K.I.Shibata,etal.;J.Immunol.165,6538(2000)
- DiscriminationofbacteriallipoproteinsbyToll-likereceptor6:O.Takeuchi,etal.;Int.Immunol.13,933(2001)
- RelationshipbetweenstructuresandbiologicalactivitiesofmycoplasmaldiacylatedlipopeptidesandtheirrecognitionbyToll-LikeReceptors2and6:T.Okusawa,etal.;Infect.Immun.72,1657(2004)
- Involvementofsuppressorsofcytokinesignalingintoll-likereceptor-mediatedblockofdendriticcelldifferentiation:H.Bartz,etal.;Blood108,4102(2006)
- Effectsofrepeatedinjectionsoffibroblast-stimulatinglipopeptide-1onfever,formationofcytokines,andontheresponsivenesstoendotoxininguinea-pigs:A.Greis,etal.;ActaPhysiol.197,35(2009)
- RegulatorsofG-proteinsignallingaremodulatedbybacteriallipopeptidesandlipopolysaccharide:S.Riekenberg,etal.;FEBSJ.276,649(2009)
- Toll-likereceptorsandinnateimmunity:H.Kumar,etal.;BBRC388,621(2009)
- LipoteichoicAcidInducesUniqueInflammatoryResponseswhenComparedtoOtherToll-LikeReceptor2Ligands:E.M.Long,etal.;PLoSOne4,e5601(2009)
- Anewcell-basedinnateimmunereceptorassayfortheexaminationofreceptoractivity,ligandspecificity,signallingpathwaysandthedetectionofpyrogens:A.Burger-Kentischer,etal.;J.Immunol.Methods358,93(2010)
- Toll-likereceptor2(P631H)mutantimpairsmembraneinternalizationandisadominantnegativeallele:G.E.Etokebe,etal.;Scand.J.Immunol.71,369(2010)
- TLR2stimulationdriveshumannaiveandeffectorregulatoryTcellsintoaTh17-likephenotypewithreducedsuppressivefunction:M.H.Nyirenda,etal.;J.Immunol.187,2278(2011)
- Asubclassofacylatedanti-inflammatorymediatorsusurpToll-likereceptor2toinhibitneutrophilrecruitmentthroughperoxisomeproliferator-activatedreceptorgamma:E.M.Long,etal.;PNAS108,16357(2011)
- ActivationofendothelialTLR2bybacteriallipoproteinupregulatesproteinsspecificfortheneutrophilresponse:K.Wilhelmsen,etal.;InnateImmun.18,602(2012)
- FcεR1-mediatedmastcellreactivityisamplifiedthroughprolongedToll-likereceptor-ligandtreatment:R.Saluja,etal.;PLoSOne7,e43547(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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